TY - JOUR
T1 - Worldwide prevalence of suicidal ideation and suicide plan among people with schizophrenia
T2 - a meta-analysis and systematic review of epidemiological surveys
AU - Bai, W.
AU - Liu, Z. H.
AU - Jiang, Y. Y.
AU - Zhang, Q. E.
AU - Rao, W. W.
AU - Cheung, T.
AU - Hall, B. J.
AU - Xiang, Y. T.
N1 - Funding Information:
The study was supported by the National Science and Technology Major Project for Investigational New Drug (2018ZX09201-014), the Beijing Municipal Science & Technology Commission (No. Z181100001518005), Scientific Research Common Programof Beijing Municipal Commission of Education (KM202010025011), Beijing Municipal Science & Tech Commission (Z191100006619061) and the University of Macau (MYRG2019-00066-FHS).
Publisher Copyright:
© 2021, The Author(s).
PY - 2021/12
Y1 - 2021/12
N2 - Schizophrenia is a severe psychiatric disorder with high premature mortality rates. This is a meta-analysis and systematic review of the prevalence of suicidal ideation (SI) and suicide plan (SP) among people with schizophrenia. PubMed, Web of Science, Embase, and PsycINFO were systematically searched from their respective inception to October 10, 2020. Data on prevalence of SI and/or SP were synthesized using the random effects model. Twenty-six studies covering 5079 people with schizophrenia were included for meta-analysis. The lifetime and point prevalence of SI were 34.5% (95% CI: 28.2−40.9%), and 29.9% (95% CI: 24.2−35.6%), respectively. The lifetime prevalence of SP was 44.3% and the point prevalence of SP ranged between 6.4 and 13%. Subgroup and meta-regression analyses revealed that source of patients, survey countries, and sample size were significantly associated with the point prevalence of SI, while male proportion and quality assessment scores were significantly associated with the lifetime and point prevalence of SI. Survey time and mean age were significantly associated with lifetime prevalence of SI. Both SI and SP are common in people living with schizophrenia, especially in males and inpatients. Routine screening and effective interventions for SI and SP should be implemented in this population.
AB - Schizophrenia is a severe psychiatric disorder with high premature mortality rates. This is a meta-analysis and systematic review of the prevalence of suicidal ideation (SI) and suicide plan (SP) among people with schizophrenia. PubMed, Web of Science, Embase, and PsycINFO were systematically searched from their respective inception to October 10, 2020. Data on prevalence of SI and/or SP were synthesized using the random effects model. Twenty-six studies covering 5079 people with schizophrenia were included for meta-analysis. The lifetime and point prevalence of SI were 34.5% (95% CI: 28.2−40.9%), and 29.9% (95% CI: 24.2−35.6%), respectively. The lifetime prevalence of SP was 44.3% and the point prevalence of SP ranged between 6.4 and 13%. Subgroup and meta-regression analyses revealed that source of patients, survey countries, and sample size were significantly associated with the point prevalence of SI, while male proportion and quality assessment scores were significantly associated with the lifetime and point prevalence of SI. Survey time and mean age were significantly associated with lifetime prevalence of SI. Both SI and SP are common in people living with schizophrenia, especially in males and inpatients. Routine screening and effective interventions for SI and SP should be implemented in this population.
UR - http://www.scopus.com/inward/record.url?scp=85118435566&partnerID=8YFLogxK
U2 - 10.1038/s41398-021-01671-6
DO - 10.1038/s41398-021-01671-6
M3 - Review article
AN - SCOPUS:85118435566
SN - 2158-3188
VL - 11
JO - Translational Psychiatry
JF - Translational Psychiatry
IS - 1
M1 - 552
ER -
