Abstract
Background and Objectives: Few studies investigated the progression of stork risk in women with migraine. Our study was to compare the growth of stroke risk between women with and without migraine by using stroke risk score, and to investigate the strength of migraine-stroke risk association among women with different migraine features.
Methods: Data from the MECH-HK cohort were used for analysis. Women with low to moderate stroke risk at baseline and younger than 60 years were included. Migraine was diagnosed through ICHD-3. Migraine features were recorded in a self-administered migraine diary. Stroke risk was assessed by 10-year China PAR stroke risk score and lifetime stroke risk score. The odds ratio (OR) and 95% confidence interval (CI) were computed for stroke risk level by multivariable logistic regression. Subgroup analyses were performed for women with different migraine features.
Results: In total 1,617 women were included in the analysis with a mean age of 51.53±7.39 years. A total of 194 (12.00%) women with migraine were identified. During an average follow up time of 1.13±0.21 years, a significant change of 10-year stroke risk score was observed among women with migraine (0.41, 95% CI: 0.33-0.50); this change was higher than those without migraine (difference of the change: 0.25, 95% CI :0.15-0.35, p<0.001). Migraine was associated with a 3.01-fold increase of developing high level stroke risk after adjusting for baseline confounding variables (95% CI: 2.00-4.51, p<0.001). Regarding the role of migraine features, stronger migraine-stroke risk associations were observed among those with migraine with aura, and those reporting frequency of 2.50-24.00 times/month, duration lasting 4.00-15.00 hours/times, and intensity rated 6.06-10.00 per times.
Conclusion: Patients with migraine showed faster growth in stroke risk compare with those without migraine among young and middle age Chinses women. The strength of the migraine-stroke risk association varied by different migraine features.
Methods: Data from the MECH-HK cohort were used for analysis. Women with low to moderate stroke risk at baseline and younger than 60 years were included. Migraine was diagnosed through ICHD-3. Migraine features were recorded in a self-administered migraine diary. Stroke risk was assessed by 10-year China PAR stroke risk score and lifetime stroke risk score. The odds ratio (OR) and 95% confidence interval (CI) were computed for stroke risk level by multivariable logistic regression. Subgroup analyses were performed for women with different migraine features.
Results: In total 1,617 women were included in the analysis with a mean age of 51.53±7.39 years. A total of 194 (12.00%) women with migraine were identified. During an average follow up time of 1.13±0.21 years, a significant change of 10-year stroke risk score was observed among women with migraine (0.41, 95% CI: 0.33-0.50); this change was higher than those without migraine (difference of the change: 0.25, 95% CI :0.15-0.35, p<0.001). Migraine was associated with a 3.01-fold increase of developing high level stroke risk after adjusting for baseline confounding variables (95% CI: 2.00-4.51, p<0.001). Regarding the role of migraine features, stronger migraine-stroke risk associations were observed among those with migraine with aura, and those reporting frequency of 2.50-24.00 times/month, duration lasting 4.00-15.00 hours/times, and intensity rated 6.06-10.00 per times.
Conclusion: Patients with migraine showed faster growth in stroke risk compare with those without migraine among young and middle age Chinses women. The strength of the migraine-stroke risk association varied by different migraine features.
| Original language | English |
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| Publication status | Published - 10 Mar 2024 |
| Event | The 27th East Asian Forum of Nursing Scholars (EAFONS) conference - The University of Hong Kong, Hong Kong, Hong Kong Duration: 10 Mar 2024 → 11 Mar 2024 https://www.eafons-2024.hku.hk/ |
Conference
| Conference | The 27th East Asian Forum of Nursing Scholars (EAFONS) conference |
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| Abbreviated title | EAFONS 2024 |
| Country/Territory | Hong Kong |
| City | Hong Kong |
| Period | 10/03/24 → 11/03/24 |
| Internet address |
Keywords
- Migraine
- Stroke
- Chinese women
ASJC Scopus subject areas
- General Health Professions
