Wide-field high-resolution structured illumination solid immersion fluorescence microscopy

Lin Wang, Mark C. Pitter, Michael Geoffrey Somekh

Research output: Journal article publicationJournal articleAcademic researchpeer-review

19 Citations (Scopus)


The use of aplanatic solid immersion lenses (ASILs) made of high-refractive-index optical materials provides a route to wide-field high-resolution optical microscopy. Structured illumination microscopy (SIM) can double the spatial bandwidth of a microscope to also achieve high-resolution imaging. We investigate the combination of ASILs and SIM in fluorescence microscopy, which we call structured illumination solid immersion fluorescence microscopy (SISIM), to pursue a microscopic system with very large NA and high lateral resolution. We demonstrate that the combination can produce a wide-field high-resolution microscopic system with bandwidth corresponding to an NA of 3. Future developments of the SISIM system to make it achieve even higher resolution are proposed.
Original languageEnglish
Pages (from-to)2794-2796
Number of pages3
JournalOptics Letters
Issue number15
Publication statusPublished - 1 Aug 2011
Externally publishedYes

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

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