Abstract
Well-defined tertiary amine-functionalized cationic polylactides (CPLAs) are synthesized by thiol-ene click functionalization of an allyl-functionalized polylactide, and utilized for the delivery of interleukin-8 (IL-8) siRNA via CPLA-IL-8 siRNA nanoplexes. The CPLAs possess remarkable hydrolytic degradability, and their cytotoxicity is relatively low. The CPLA-IL-8 siRNA nanoplexes can be readily taken up by prostate cancer cells, resulting in significant IL-8 gene silencing. It is found that the degradability and cytotoxicity of CPLAs, as well as the transfection efficiency of the CPLA-IL-8 siRNA nanoplexes, positively correlate with the amine mol% of CPLAs. KGaA, Weinheim.
Original language | English |
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Pages (from-to) | 751-761 |
Number of pages | 11 |
Journal | Advanced healthcare materials |
Volume | 1 |
Issue number | 6 |
DOIs | |
Publication status | Published - 1 Nov 2012 |
Externally published | Yes |
Keywords
- Cationic polymer
- Degradable polymer
- Gene delivery
- Prostate cancer
- RNAi
ASJC Scopus subject areas
- Biomaterials
- Biomedical Engineering
- Pharmaceutical Science