Well-Defined Degradable Cationic Polylactide as Nanocarrier for the Delivery of siRNA to Silence Angiogenesis in Prostate Cancer

Chih Kuang Chen, Wing Cheung Law, Ravikumar Aalinkeel, Bindukumar Nair, Atcha Kopwitthaya, Supriya D. Mahajan, Jessica L. Reynolds, Jiong Zou, Stanley A. Schwartz, Paras N. Prasad, Chong Cheng

Research output: Journal article publicationJournal articleAcademic researchpeer-review

60 Citations (Scopus)

Abstract

Well-defined tertiary amine-functionalized cationic polylactides (CPLAs) are synthesized by thiol-ene click functionalization of an allyl-functionalized polylactide, and utilized for the delivery of interleukin-8 (IL-8) siRNA via CPLA-IL-8 siRNA nanoplexes. The CPLAs possess remarkable hydrolytic degradability, and their cytotoxicity is relatively low. The CPLA-IL-8 siRNA nanoplexes can be readily taken up by prostate cancer cells, resulting in significant IL-8 gene silencing. It is found that the degradability and cytotoxicity of CPLAs, as well as the transfection efficiency of the CPLA-IL-8 siRNA nanoplexes, positively correlate with the amine mol% of CPLAs. KGaA, Weinheim.
Original languageEnglish
Pages (from-to)751-761
Number of pages11
JournalAdvanced healthcare materials
Volume1
Issue number6
DOIs
Publication statusPublished - 1 Nov 2012
Externally publishedYes

Keywords

  • Cationic polymer
  • Degradable polymer
  • Gene delivery
  • Prostate cancer
  • RNAi

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Pharmaceutical Science

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