Well-Defined Degradable Cationic Polylactide as Nanocarrier for the Delivery of siRNA to Silence Angiogenesis in Prostate Cancer

Chih Kuang Chen; Wing Cheung Law; Ravikumar Aalinkeel; Bindukumar Nair; Atcha Kopwitthaya; Supriya D. Mahajan; Jessica L. Reynolds; Jiong Zou; Stanley A. Schwartz; Paras N. Prasad; Chong Cheng

doi:10.1002/adhm.201200094

Well-Defined Degradable Cationic Polylactide as Nanocarrier for the Delivery of siRNA to Silence Angiogenesis in Prostate Cancer

Chih Kuang Chen, Wing Cheung Law, Ravikumar Aalinkeel, Bindukumar Nair, Atcha Kopwitthaya, Supriya D. Mahajan, Jessica L. Reynolds, Jiong Zou, Stanley A. Schwartz, Paras N. Prasad, Chong Cheng

Research output: Journal article publication › Journal article › Academic research › peer-review

62 Citations (Scopus)

Abstract

Well-defined tertiary amine-functionalized cationic polylactides (CPLAs) are synthesized by thiol-ene click functionalization of an allyl-functionalized polylactide, and utilized for the delivery of interleukin-8 (IL-8) siRNA via CPLA-IL-8 siRNA nanoplexes. The CPLAs possess remarkable hydrolytic degradability, and their cytotoxicity is relatively low. The CPLA-IL-8 siRNA nanoplexes can be readily taken up by prostate cancer cells, resulting in significant IL-8 gene silencing. It is found that the degradability and cytotoxicity of CPLAs, as well as the transfection efficiency of the CPLA-IL-8 siRNA nanoplexes, positively correlate with the amine mol% of CPLAs. KGaA, Weinheim.

Original language	English
Pages (from-to)	751-761
Number of pages	11
Journal	Advanced healthcare materials
Volume	1
Issue number	6
DOIs	https://doi.org/10.1002/adhm.201200094
Publication status	Published - 1 Nov 2012
Externally published	Yes

Keywords

Cationic polymer
Degradable polymer
Gene delivery
Prostate cancer
RNAi

ASJC Scopus subject areas

Biomaterials
Biomedical Engineering
Pharmaceutical Science

More information

10.1002/adhm.201200094

Cite this

Chen, C. K., Law, W. C., Aalinkeel, R., Nair, B., Kopwitthaya, A., Mahajan, S. D., Reynolds, J. L., Zou, J., Schwartz, S. A., Prasad, P. N., & Cheng, C. (2012). Well-Defined Degradable Cationic Polylactide as Nanocarrier for the Delivery of siRNA to Silence Angiogenesis in Prostate Cancer. Advanced healthcare materials, 1(6), 751-761. https://doi.org/10.1002/adhm.201200094

Chen, Chih Kuang ; Law, Wing Cheung ; Aalinkeel, Ravikumar ; Nair, Bindukumar ; Kopwitthaya, Atcha ; Mahajan, Supriya D. ; Reynolds, Jessica L. ; Zou, Jiong ; Schwartz, Stanley A. ; Prasad, Paras N. ; Cheng, Chong. / Well-Defined Degradable Cationic Polylactide as Nanocarrier for the Delivery of siRNA to Silence Angiogenesis in Prostate Cancer. In: Advanced healthcare materials. 2012 ; Vol. 1, No. 6. pp. 751-761.

@article{dfa724372c5e4ddbb7f00c36463065e8,

title = "Well-Defined Degradable Cationic Polylactide as Nanocarrier for the Delivery of siRNA to Silence Angiogenesis in Prostate Cancer",

abstract = "Well-defined tertiary amine-functionalized cationic polylactides (CPLAs) are synthesized by thiol-ene click functionalization of an allyl-functionalized polylactide, and utilized for the delivery of interleukin-8 (IL-8) siRNA via CPLA-IL-8 siRNA nanoplexes. The CPLAs possess remarkable hydrolytic degradability, and their cytotoxicity is relatively low. The CPLA-IL-8 siRNA nanoplexes can be readily taken up by prostate cancer cells, resulting in significant IL-8 gene silencing. It is found that the degradability and cytotoxicity of CPLAs, as well as the transfection efficiency of the CPLA-IL-8 siRNA nanoplexes, positively correlate with the amine mol% of CPLAs. KGaA, Weinheim.",

keywords = "Cationic polymer, Degradable polymer, Gene delivery, Prostate cancer, RNAi",

author = "Chen, {Chih Kuang} and Law, {Wing Cheung} and Ravikumar Aalinkeel and Bindukumar Nair and Atcha Kopwitthaya and Mahajan, {Supriya D.} and Reynolds, {Jessica L.} and Jiong Zou and Schwartz, {Stanley A.} and Prasad, {Paras N.} and Chong Cheng",

year = "2012",

month = nov,

day = "1",

doi = "10.1002/adhm.201200094",

language = "English",

volume = "1",

pages = "751--761",

journal = "Advanced healthcare materials",

issn = "2192-2640",

publisher = "John Wiley and Sons Ltd",

number = "6",

}

Well-Defined Degradable Cationic Polylactide as Nanocarrier for the Delivery of siRNA to Silence Angiogenesis in Prostate Cancer. / Chen, Chih Kuang; Law, Wing Cheung; Aalinkeel, Ravikumar; Nair, Bindukumar; Kopwitthaya, Atcha; Mahajan, Supriya D.; Reynolds, Jessica L.; Zou, Jiong; Schwartz, Stanley A.; Prasad, Paras N.; Cheng, Chong.

In: Advanced healthcare materials, Vol. 1, No. 6, 01.11.2012, p. 751-761.

Research output: Journal article publication › Journal article › Academic research › peer-review

TY - JOUR

T1 - Well-Defined Degradable Cationic Polylactide as Nanocarrier for the Delivery of siRNA to Silence Angiogenesis in Prostate Cancer

AU - Chen, Chih Kuang

AU - Law, Wing Cheung

AU - Aalinkeel, Ravikumar

AU - Nair, Bindukumar

AU - Kopwitthaya, Atcha

AU - Mahajan, Supriya D.

AU - Reynolds, Jessica L.

AU - Zou, Jiong

AU - Schwartz, Stanley A.

AU - Prasad, Paras N.

AU - Cheng, Chong

PY - 2012/11/1

Y1 - 2012/11/1

N2 - Well-defined tertiary amine-functionalized cationic polylactides (CPLAs) are synthesized by thiol-ene click functionalization of an allyl-functionalized polylactide, and utilized for the delivery of interleukin-8 (IL-8) siRNA via CPLA-IL-8 siRNA nanoplexes. The CPLAs possess remarkable hydrolytic degradability, and their cytotoxicity is relatively low. The CPLA-IL-8 siRNA nanoplexes can be readily taken up by prostate cancer cells, resulting in significant IL-8 gene silencing. It is found that the degradability and cytotoxicity of CPLAs, as well as the transfection efficiency of the CPLA-IL-8 siRNA nanoplexes, positively correlate with the amine mol% of CPLAs. KGaA, Weinheim.

AB - Well-defined tertiary amine-functionalized cationic polylactides (CPLAs) are synthesized by thiol-ene click functionalization of an allyl-functionalized polylactide, and utilized for the delivery of interleukin-8 (IL-8) siRNA via CPLA-IL-8 siRNA nanoplexes. The CPLAs possess remarkable hydrolytic degradability, and their cytotoxicity is relatively low. The CPLA-IL-8 siRNA nanoplexes can be readily taken up by prostate cancer cells, resulting in significant IL-8 gene silencing. It is found that the degradability and cytotoxicity of CPLAs, as well as the transfection efficiency of the CPLA-IL-8 siRNA nanoplexes, positively correlate with the amine mol% of CPLAs. KGaA, Weinheim.

KW - Cationic polymer

KW - Degradable polymer

KW - Gene delivery

KW - Prostate cancer

KW - RNAi

UR - http://www.scopus.com/inward/record.url?scp=84874582391&partnerID=8YFLogxK

U2 - 10.1002/adhm.201200094

DO - 10.1002/adhm.201200094

M3 - Journal article

C2 - 23184827

VL - 1

SP - 751

EP - 761

JO - Advanced healthcare materials

JF - Advanced healthcare materials

SN - 2192-2640

IS - 6

ER -

Well-Defined Degradable Cationic Polylactide as Nanocarrier for the Delivery of siRNA to Silence Angiogenesis in Prostate Cancer

Abstract

Keywords

ASJC Scopus subject areas

More information

Other files and links

Cite this