Wavelet coherence analysis of prefrontal tissue oxyhaemoglobin signals as measured using near-infrared spectroscopy in elderly subjects with cerebral infarction

Qingyu Han, Ming Zhang, Wenhao Li, Yuanjin Gao, Qing Xin, Yan Wang, Zengyong Li

Research output: Journal article publicationJournal articleAcademic researchpeer-review

15 Citations (Scopus)

Abstract

This study aims to assess the prefrontal functional connectivity using wavelet coherence analysis of cerebral tissue oxyhaemoglobin concentration (Delta [HbO2]) signals in elderly subjects with cerebral infarction (CI) during the resting state. Continuous recordings of near-infrared spectroscopy (NIRS) signals were obtained from the left and right prefrontal lobes in 10 subjects with CI (age: 74.4±9.0years) and 18 healthy elderly subjects (age: 69.9±7.3years) during the resting state. The coherence between left and right prefrontal Delta [HbO2] oscillations in four frequency intervals (I, 0.6-2Hz; II, 0.145-0.6Hz; III, 0.052-0.145Hz and IV, 0.021-0.052Hz) was analyzed using wavelet coherence analysis. In healthy elderly subjects, the Delta [HbO2] oscillations were significantly wavelet coherent in intervals I and III (p<0.05), wavelet phase coherent in intervals from I to IV. In elderly subjects with CI, the left and right Delta [HbO2] oscillations were significantly wavelet coherent and phase coherent in interval I (p<0.05). In elderly subjects with CI, the power and phase coherences were significantly lower in interval III (p<0.01) than in healthy subjects. The difference in wavelet coherence between the healthy elderly and elderly with CI indicates an altered brain functional connectivity in CI patients. This may be useful for assessing the effectiveness of functional recovery following a CI.
Original languageEnglish
Pages (from-to)108-115
Number of pages8
JournalMicrovascular Research
Volume95
Issue number1
DOIs
Publication statusPublished - 1 Jan 2014

Keywords

  • Cerebral infarction
  • Cerebral oxygenation
  • Elderly
  • Functional connectivity
  • Near-infrared spectroscopy
  • Phase coherence
  • Prefrontal cortex
  • Resting state
  • Spontaneous oscillations
  • Wavelet coherence

ASJC Scopus subject areas

  • Biochemistry
  • Cardiology and Cardiovascular Medicine
  • Cell Biology

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