Virus infectivity detection by effective refractive index using optofluidic imaging

  • P. Y. Liu
  • , L. K. Chin
  • , W. Ser
  • , T. C. Ayi
  • , P. H. Yap
  • , T. Bourouina
  • , Y. Leprince-Wang

Research output: Chapter in book / Conference proceedingConference article published in proceeding or bookAcademic researchpeer-review

2 Citations (Scopus)

Abstract

This paper presents an optofluidic imaging system to detect influenza virus infection via co-culture of Madin Darby Canine Kidney (MDCK) cells. Influenza flu virus is a serious threat that can cause contagious infections in people in epidemic proportions. Hence, it is crucial to accurately detect and understand the morphological changes that occur in the cells when infected by the influenza virus. Recently, researchers are investigating the biophysical properties of cells and correlating them to biomedical conditions. For example, a decrease in refractive index (RI) is observed in bacterial infected cells [1]. In this paper, an optofluidic imaging system is developed to observe the change of RI in virus infected cells based on scattering signature.

Original languageEnglish
Title of host publication18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
PublisherChemical and Biological Microsystems Society
Pages2309-2311
Number of pages3
ISBN (Electronic)9780979806476
Publication statusPublished - 2014
Event18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 - San Antonio, United States
Duration: 26 Oct 201430 Oct 2014

Publication series

Name18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

Conference

Conference18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
Country/TerritoryUnited States
CitySan Antonio
Period26/10/1430/10/14

Keywords

  • Optofluidics
  • Scattering signature
  • Virus infectivity

ASJC Scopus subject areas

  • Control and Systems Engineering

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