Verbal learning in Alzheimer's dementia

May Lan Alma Mary Gerardina Au, Agnes S. Chan, Helen Chiu

Research output: Journal article publicationReview articleAcademic researchpeer-review

22 Citations (Scopus)

Abstract

Many recent findings in Western countries suggest that episodic recall is the most sensitive discriminator between patients with mild Alzheimer disease (AD) and the normal elderly, while semantic memory tends best to differentiate between moderate and severe AD patients. The present study is the first to examine in detail the episodic memory of Chinese AD patients in Hong Kong with a locally developed list learning test, comparing procedures that do or do not encourage the use of semantic organization. The performance of 28 AD patients was compared to that of 30 normal controls. AD patients did significantly worse in terms of acquisition and retention and also benefited significantly less from external organization cues. In the discriminant function analysis, the rate of forgetting in the random condition and the total retention score in the blocked condition were found to be the best predictors for differentiating between AD patients and controls. On the other hand, in the differentiation between mild and moderate AD, semantic clustering in the blocked condition was found to be the best predictor. Results of the present study were discussed in the light of the previous findings reported in the Western countries and the neuropathological changes of AD patients.
Original languageEnglish
Pages (from-to)363-375
Number of pages13
JournalJournal of the International Neuropsychological Society
Volume9
Issue number3
DOIs
Publication statusPublished - 1 Mar 2003
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Episodic memory
  • Semantic memory
  • Verbal learning

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Clinical Neurology
  • Psychiatry and Mental health

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