VEGF121-conjugated mesoporous silica nanoparticle: A tumor targeted drug delivery system

Shreya Goel, Feng Chen, Hao Hong, Hector F. Valdovinos, Reinier Hernandez, Sixiang Shi, Todd E. Barnhart, Weibo Cai

Research output: Journal article publicationJournal articleAcademic researchpeer-review

84 Citations (Scopus)

Abstract

The vascular endothelial growth factor (VEGF)/VEGF receptor (VEGFR) signaling cascade plays a critical role in tumor angiogenesis and metastasis and has been correlated with several poorly prognostic cancers such as malignant gliomas. Although a number of anti-VEGFR therapies have been conceived, inefficient drug administration still limits their therapeutic efficacy and raises concerns of potential side effects. In the present work, we propose the use of uniform mesoporous silica nanoparticles (MSNs) for VEGFR targeted positron emission tomography imaging and delivery of the anti-VEGFR drug (i.e., sunitinib) in human glioblastoma (U87MG) bearing murine models. MSNs were synthesized, characterized and modified with polyethylene glycol, anti-VEGFR ligand VEGF121 and radioisotope 64Cu, followed by extensive in vitro, in vivo and ex vivo studies. Our results demonstrated that a significantly higher amount of sunitinib could be delivered to the U87MG tumor by targeting VEGFR when compared with the non-targeted counterparts. The as-developed VEGF121-conjugated MSN could become another attractive nanoplatform for the design of future theranostic nanomedicine.

Original languageEnglish
Pages (from-to)21677-21685
Number of pages9
JournalACS Applied Materials and Interfaces
Volume6
Issue number23
Early online date10 Nov 2014
DOIs
Publication statusPublished - 10 Dec 2014
Externally publishedYes

Keywords

  • drug delivery
  • mesoporous silica nanoparticle
  • positron emission tomography
  • vasculature targeting
  • VEGFR

ASJC Scopus subject areas

  • Materials Science(all)

Cite this