VEGFR targeting leads to significantly enhanced tumor uptake of nanographene oxide invivo

Sixiang Shi, Kai Yang, Hao Hong, Feng Chen, Hector F. Valdovinos, Shreya Goel, Todd E. Barnhart, Zhuang Liu, Weibo Cai

Research output: Journal article publicationJournal articleAcademic researchpeer-review

49 Citations (Scopus)

Abstract

Although graphene oxide (GO) has recently been considered as a highly attractive nanomaterial for future cancer imaging and therapy, it is still a major challenge to improve its invivo tumor active targeting efficiency. Here in this full article, we demonstrated the successful and significantly enhanced invivo tumor vasculature targeting efficacy of well-functionalized GO nanoconjugates by using vascular endothelial growth factor 121 (VEGF121) as the targeting ligand. As-developed GO nanoconjugate exhibits excellent invivo stability, specific invitro and invivo vascular endothelial growth factor receptor (VEGFR) targeting, significantly enhanced tumor accumulation (>8 %ID/g) as well as high tumor-to-muscle contrast, showing great potential for future tumor targeted imaging and therapy.

Original languageEnglish
Pages (from-to)39-46
Number of pages8
JournalBiomaterials
Volume39
DOIs
Publication statusPublished - Jan 2015
Externally publishedYes

Keywords

  • Graphene oxide (GO)
  • Positron emission tomography (PET)
  • Vasculature targeting
  • VEGF

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

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