Use of magnetic nanoparticles to visualize threadlike structures inside lymphatic vessels of rats

Hyeon Min Johng, Jung Sun Yoo, Tae Jong Yoon, Hak Soo Shin, Byung Cheon Lee, Changhoon Lee, Jin Kyu Lee, Kwang Sup Soh

Research output: Journal article publicationJournal articleAcademic researchpeer-review

80 Citations (Scopus)


A novel application of fluorescent magnetic nanoparticles was made to visualize a new tissue which had not been detectable by using simple stereomicroscopes. This unfamiliar threadlike structure inside the lymphatic vessels of rats was demonstrated in vivo by injecting nanoparticles into lymph nodes and applying magnetic fields on the collecting lymph vessels so that the nanoparticles were taken up by the threadlike structures. Confocal laser scanning microscope images of cryosectioned specimens exhibited that the nanoparticles were absorbed more strongly by the threadlike structure than by the lymphatic vessels. Further examination using a transmission electron microscope revealed that the nanoparticles had been captured between the reticular fibers in the extracellular matrix of the threadlike structures. The emerging technology of nanoparticles not only allows the extremely elusive threadlike structures to be visualized but also is expected to provide a magnetically controllable means to investigate their physiological functions.
Original languageEnglish
Pages (from-to)77-82
Number of pages6
JournalEvidence-based Complementary and Alternative Medicine
Issue number1
Publication statusPublished - 1 Mar 2007
Externally publishedYes


  • Acupuncture meridian
  • Bonghan duct
  • Lymph
  • Nanoparticle
  • Transmission electron microscope

ASJC Scopus subject areas

  • Complementary and alternative medicine


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