Abstract
Background: The mechanism of botulinum neurotoxin D light chain (LC/D) substrate recognition is not well defined. Results: A dual recognition strategy employed by LC/D was revealed, in which one site of VAMP-2 was recognized by two independent, functionally similar LC/D sites that were complementary to each other. Conclusion: LC/D utilizes a unique mechanism for substrate recognition. Significance: This study provides insights for LC/D engineering and antitoxin development.
| Original language | English |
|---|---|
| Pages (from-to) | 27881-27887 |
| Number of pages | 7 |
| Journal | Journal of Biological Chemistry |
| Volume | 288 |
| Issue number | 39 |
| DOIs | |
| Publication status | Published - 27 Sept 2013 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology