Unique substrate recognition mechanism of the botulinum neurotoxin D light chain

Jiubiao Guo, Sheng Chen

Research output: Journal article publicationJournal articleAcademic researchpeer-review

8 Citations (Scopus)


Background: The mechanism of botulinum neurotoxin D light chain (LC/D) substrate recognition is not well defined. Results: A dual recognition strategy employed by LC/D was revealed, in which one site of VAMP-2 was recognized by two independent, functionally similar LC/D sites that were complementary to each other. Conclusion: LC/D utilizes a unique mechanism for substrate recognition. Significance: This study provides insights for LC/D engineering and antitoxin development.
Original languageEnglish
Pages (from-to)27881-27887
Number of pages7
JournalJournal of Biological Chemistry
Issue number39
Publication statusPublished - 27 Sep 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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