Ultrasound-modulated optical tomography at new depth

Puxiang Lai, Xiao Xu, Lihong V. Wang

Research output: Journal article publicationJournal articleAcademic researchpeer-review

23 Citations (Scopus)

Abstract

Ultrasound-modulated optical tomography (UOT) has the potential to reveal optical contrast deep inside soft biological tissues at an ultrasonically determined spatial resolution. The optical imaging depth reported so far has, however, been limited, which prevents this technique from broader applications. Our latest experimental exploration has pushed UOT to an unprecedented imaging depth. We developed and optimized a UOT system employing a photorefractive crystal-based interferometer. A large aperture optical fiber bundle was used to enhance the efficiencies for diffuse light collection and photorefractive two-wave-mixing. Within the safety limits for both laser illumination and ultrasound modulation, the system has attained the ability to image through a tissue-mimicking phantom of 9.4 cm in thickness, which has never been reached previously by UOT.
Original languageEnglish
Article number066006
JournalJournal of Biomedical Optics
Volume17
Issue number6
DOIs
Publication statusPublished - 1 Jun 2012
Externally publishedYes

Keywords

  • Acousto-optic imaging
  • Fiber bundle
  • Light guide
  • Optical imaging
  • Photorefractive crystal
  • Tissue-mimicking phantom
  • Two-wave-mixing
  • Ultrasound modulation
  • Ultrasound-modulated optical tomography

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering

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