Ultrasensitive and rapid screening of mercury(II) ions by dual labeling colorimetric method in aqueous samples and applications in mercury-poisoned animal tissues

Yi Deng, Xin Wang, Feng Xue, Lei Zheng, Jian Liu, Feng Yan, Fan Xia, Wei Chen

Research output: Journal article publicationJournal articleAcademic researchpeer-review

17 Citations (Scopus)


Rapid and ultrasensitive detection of trace heavy metal mercury(II) ions (Hg2+) are of significant importance due to the induced serious risks for environment and human health. This presented article reports the gold nanoparticle-based dual labeling colorimetric method (Dual-COLO) for ultrasensitive and rapid detection of Hg2+using the specific thymine-Hg2+-thymine (T-Hg2+-T) as recognition system and the dual labeling strategy for signal amplification. Both qualitative and quantitative detections of Hg2+are achieved successfully in aqueous samples. More importantly, the achieved detection limit of 0.005ngmL-1(0.025nM) without any instruments is very competitive to other rapid detection methods even ICP-MS based methods. This Dual-COLO method is also applied directly for real water sample monitoring and, more importantly, applied in analysis of mercury poisoned animal tissues and body fluidic samples, indicating a potentially powerful and promising tool for environmental monitoring and food safety control.
Original languageEnglish
Pages (from-to)45-52
Number of pages8
JournalAnalytica Chimica Acta
Publication statusPublished - 8 Apr 2015


  • Dual labeling colorimetric method
  • Hg detection 2+
  • Mercury poisoned animal tissues
  • Signal amplification

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Environmental Chemistry
  • Spectroscopy

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