Ultraminiature optical fiber-tip directly-printed plasmonic biosensors for label-free biodetection

Yangxi Zhang, Hao Wu, Han Wang, Bohan Yin, Siu Hong Dexter Wong, A. Ping Zhang, Hwa Yaw Tam

Research output: Journal article publicationJournal articleAcademic researchpeer-review

10 Citations (Scopus)

Abstract

Miniaturization of biosensors has become an imperative demand because of its great potential in in vivo biomarker detection and disease diagnostics as well as the point-of-care testing for coping with public health crisis, such as the coronavirus disease 2019 pandemic. Here, we present an ultraminiature optical fiber-tip biosensor based on the plasmonic gold nanoparticles (AuNPs) directly printed upon the end face of a standard multimode optical fiber at visible light range. An in-situ precision photoreduction technology is developed to additively print the micropatterns of size-controlled AuNPs. The AuNPs reveal distinct localized surface plasmon resonance, whose peak wavelength provides an ideal spectral signal for label-free biodetection. The fabricated optical fiber-tip plasmonic biosensor can not only detect antibody, but also test SARS-CoV-2 mimetic DNA sequence at the concentration level of 0.8 pM. Such an ultraminiature fiber-tip plasmonic biosensor offers a cost-effective biodetection technology for a myriad of applications ranging from point-of-care testing to in vivo diagnosis of stubborn diseases.

Original languageEnglish
Article number114761
JournalBiosensors and Bioelectronics
Volume218
DOIs
Publication statusPublished - 15 Dec 2022

Keywords

  • Additive printing
  • Gold nanoparticles
  • Optical fiber sensors
  • Plasmonic biosensor
  • Precision photoreduction

ASJC Scopus subject areas

  • Biotechnology
  • Biophysics
  • Biomedical Engineering
  • Electrochemistry

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