Ultraminiature optical fiber-tip directly-printed plasmonic biosensors for label-free biodetection

Yangxi Zhang, Hao Wu, Han Wang, Bohan Yin, Siu Hong Dexter Wong, A. Ping Zhang, Hwa Yaw Tam

Research output: Journal article publicationJournal articleAcademic researchpeer-review

10 Citations (Scopus)


Miniaturization of biosensors has become an imperative demand because of its great potential in in vivo biomarker detection and disease diagnostics as well as the point-of-care testing for coping with public health crisis, such as the coronavirus disease 2019 pandemic. Here, we present an ultraminiature optical fiber-tip biosensor based on the plasmonic gold nanoparticles (AuNPs) directly printed upon the end face of a standard multimode optical fiber at visible light range. An in-situ precision photoreduction technology is developed to additively print the micropatterns of size-controlled AuNPs. The AuNPs reveal distinct localized surface plasmon resonance, whose peak wavelength provides an ideal spectral signal for label-free biodetection. The fabricated optical fiber-tip plasmonic biosensor can not only detect antibody, but also test SARS-CoV-2 mimetic DNA sequence at the concentration level of 0.8 pM. Such an ultraminiature fiber-tip plasmonic biosensor offers a cost-effective biodetection technology for a myriad of applications ranging from point-of-care testing to in vivo diagnosis of stubborn diseases.

Original languageEnglish
Article number114761
JournalBiosensors and Bioelectronics
Publication statusPublished - 15 Dec 2022


  • Additive printing
  • Gold nanoparticles
  • Optical fiber sensors
  • Plasmonic biosensor
  • Precision photoreduction

ASJC Scopus subject areas

  • Biotechnology
  • Biophysics
  • Biomedical Engineering
  • Electrochemistry


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