Ultrafast polarization bio-imaging based on coherent detection and time-stretch techniques

Lu Song, Yuanhua Feng, Xiaojie Guo, Yuecheng Shen, Daixuan Wu, Zhenhua Wu, Congran Zhou, Linyan Zhu, Shecheng Gao, Weiping Liu, Xuming Zhang, Zhaohui Li

Research output: Journal article publicationJournal articleAcademic researchpeer-review

1 Citation (Scopus)

Abstract

Optical polarization imaging has played an important role in many biological and biomedical applications, as it provides a label-free and non-invasive detection scheme to reveal the polarization information of optical rotation, birefringence, and photoelasticity distribution inherent in biological samples. However, the imaging speeds of the previously demonstrated polarization imaging techniques were often limited by the slow frame rates of the arrayed imaging detectors, which usually run at frame rates of several hundred hertz. By combining the optical coherent detection of orthogonal polarizations and the optical time-stretch imaging technique, we achieved ultrafast polarization bio-imaging at an extremely fast record line scanning rate up to 100 MHz without averaging. We experimentally demonstrated the superior performance of our method by imaging three slices of different kinds of biological samples with the retrieved Jones matrix and polarization-sensitive information including birefringence and diattenuation. The proposed system in this paper may find potential applications for ultrafast polarization dynamics in living samples or some other advanced biomedical research.

Original languageEnglish
Article number#347625
Pages (from-to)6556-6568
Number of pages13
JournalBiomedical Optics Express
Volume9
Issue number12
DOIs
Publication statusPublished - 1 Dec 2018

ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics

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