Two-stage degradation and novel functional endothelium characteristics of a 3-D printed bioresorbable scaffold

Tieying Yin, Ruolin Du, Yang Wang, Junyang Huang, Shuang Ge, Yuhua Huang, Youhua Tan, Qing Liu, Zhong Chen, Hanqing Feng, Jie Du, Yazhou Wang, Guixue Wang

Research output: Journal article publicationJournal articleAcademic researchpeer-review

23 Citations (Scopus)

Abstract

Bioresorbable scaffolds have emerged as a new generation of vascular implants for the treatment of atherosclerosis, and designed to provide a temporary scaffold that is subsequently absorbed by blood vessels over time. Presently, there is insufficient data on the biological and mechanical responses of blood vessels accompanied by bioresorbable scaffolds (BRS) degradation. Therefore, it is necessary to investigate the inflexion point of degradation, the response of blood vessels, and the pathophysiological process of vascular, as results of such studies will be of great value for the design of next generation of BRS. In this study, abdominal aortas of SD rats were received 3-D printed poly-l-actide vascular scaffolds (PLS) for various durations up to 12 months. The response of PLS implanted aorta went through two distinct processes: (1) the neointima with desirable barrier function was obtained in 1 month, accompanied with slow degradation, inflammation, and intimal hyperplasia; (2) significant degradation occurred from 6 months, accompanied with decreasing inflammation and intimal hyperplasia, while the extracellular matrix recovered to normal vessels which indicate the positive remodeling. These in vivo results indicate that 6 months is a key turning point. This “two-stage degradation and vascular characteristics” is proposed to elucidate the long-term effects of PLS on vascular repair and demonstrated the potential of PLS in promoting endothelium function and positive remodeling, which highlights the benefits of PLS and shed some light in the future researches, such as drug combination coatings design.
Original languageEnglish
Article number34901554
Pages (from-to)378-396
Number of pages19
JournalBioactive Materials
Volume10
Issue numberApril 2022
DOIs
Publication statusPublished - 24 Aug 2021

Keywords

  • Intravascular stents
  • 3-D printing
  • Bioresorbable scaffold
  • Degradation behavior
  • Functional endothelium

ASJC Scopus subject areas

  • Cancer Research

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