Two-photon microscopy study of the intracellular compartmentalisation of emissive terbium complexes and their oligo-arginine and oligo-guanidinium conjugates

Filip Kielar, Aileen Congreve, Ga Lai Law, Elizabeth J. New, David Parker, Ka Leung Wong, Pilar Castreňo, Javier De Mendoza

Research output: Journal article publicationJournal articleAcademic researchpeer-review

83 Citations (Scopus)

Abstract

An emissive terbium complex has been conjugated to a C12 chain, Lys-Arg7, Arg7, a tetraguanidinium cation and human serum albumin; two-photon excitation at 720 nm facilitated microscopy studies revealing cell localisation profiles with the oligo-guanidinium conjugate localising in mitochondria but causing apoptotic cell death (IC5012 μM), the C12-amide complex giving rise to necrotic cell death in skin fibroblasts (IC50 8 μM) and the peptide conjugates and the methyl ester generating punctuate cytosolic intracellular distributions.
Original languageEnglish
Pages (from-to)2435-2437
Number of pages3
JournalChemical Communications
Issue number21
DOIs
Publication statusPublished - 27 May 2008
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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