Two new phenylpropanoids and one new sesquiterpenoid from the bioactive fraction of Sambucus williamsii

Hui Hui Xiao, Yi Dai, Man Sau Wong, Xin Sheng Yao

Research output: Journal article publicationJournal articleAcademic researchpeer-review

5 Citations (Scopus)

Abstract

Two new phenylpropanoids, samwirin (1) and samwiphenol (2), and a new sesquiterpenoid, 2β,4β,10α-trihydroxy-1αH,5βH-guaia-6-ene (3), together with six known compounds were isolated from the bioactive fraction of Sambucus williamsii Hance. Their structures including the absolute configurations were characterized on the basis of extensive 1D, 2D-NMR, MS, and CD spectral data. In vitro proliferation effects of all compounds on osteoblast-like UMR 106 cells were examined. Compounds 1, 4-9 significantly promoted cell proliferation. Compounds 5, 6, and 8 increased osteoblastic cell numbers separately by 24.3%, 25.2%, and 29.1% at 10-10M, 10-10M, and 10-8M, respectively.
Original languageEnglish
Pages (from-to)625-632
Number of pages8
JournalJournal of Asian Natural Products Research
Volume17
Issue number6
DOIs
Publication statusPublished - 5 Jun 2015

Keywords

  • Caprifoliaceae
  • phenylpropanoid
  • proliferation effects
  • Sambucus williamsii
  • sesquiterpenoid
  • UMR 106 cells

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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