Two-dimensional surface plasmon resonance biosensor array based on phase-sensitive measurement

H. P. Ho, K. S. Chan, C. L. Wong, K. F. Lei, W. I. Li, Wing Cheung Law, S. Y. Wu, S. K. Kong, C. Lin

Research output: Journal article publicationConference articleAcademic researchpeer-review

4 Citations (Scopus)

Abstract

We report a 2-dimensional surface plasmon resonance (SPR) imaging array sensor based on differential phase measurement between p- and s-polarization. This parallel detection provides the advantage of high-throughput sensing, which is essential in recent biosensing technology. In the differential measurement approach, the signal (p) and reference (s) beams go through exactly identical optical path. This greatly improves the phase detection stability. In the present setup we use a low-cost imaging device and a simple data analysis program to perform the required arrayed sensing operation. The system demonstrates a refractive index resolution of 1×10-4RIU per degree phase change.
Original languageEnglish
Article number59270E
Pages (from-to)1-10
Number of pages10
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume5927
DOIs
Publication statusPublished - 1 Dec 2005
Externally publishedYes
EventPlasmonics: Metallic Nanostructures and Their Optical Properties III - San Diego, CA, United States
Duration: 31 Jul 20053 Aug 2005

Keywords

  • Biosensors
  • Imaging
  • Interference
  • Surface plasmon resonance

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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