Two dimensional phase sensitive surface plasmon resonance biosensor array using microfluidic flow circuit platform

Chi Lok Wong, Ho Pui Ho, Kin Fong Lei, Wen Jung Li, Kwok Sum Chan, Wing Cheung Law, Shu Yuen Wu, Siu Kai Kong, Chinlon Lin

Research output: Chapter in book / Conference proceedingConference article published in proceeding or bookAcademic researchpeer-review

Abstract

The integration between 2D SPR differential phase imaging sensor and microfluidic flow circuit is presented. It provides the advantages of high throughput, high sensitivity and label free detection to meet the present needs in biomechanical market. The differential phase scheme between p- and s- polarization enable elimination of all common-path phase noise while keeping the phase change caused by SPR effect. System sensitivity of the detection sensitivity of our setup is 0.44μg /ml is obtained for salt / water mixture sensing. BSA antigen and antibody binding reaction detection is further demonstrated. The system shows the capability of simultaneous detection for both specific and non-specific binding reactions in a micro-chamber array.
Original languageEnglish
Title of host publication2005 IEEE Conference on Electron Devices and Solid-State Circuits, EDSSC
Pages709-712
Number of pages4
DOIs
Publication statusPublished - 1 Dec 2006
Externally publishedYes
Event2005 IEEE Conference on Electron Devices and Solid-State Circuits, EDSSC - Howloon, Hong Kong
Duration: 19 Dec 200521 Dec 2005

Conference

Conference2005 IEEE Conference on Electron Devices and Solid-State Circuits, EDSSC
CountryHong Kong
CityHowloon
Period19/12/0521/12/05

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Electronic, Optical and Magnetic Materials

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