Two dimensional phase sensitive surface plasmon resonance biosensor array using microfluidic flow circuit platform

Chi Lok Wong; Ho Pui Ho; Kin Fong Lei; Wen Jung Li; Kwok Sum Chan; Wing Cheung Law; Shu Yuen Wu; Siu Kai Kong; Chinlon Lin

doi:10.1109/EDSSC.2005.1635374

Two dimensional phase sensitive surface plasmon resonance biosensor array using microfluidic flow circuit platform

Chi Lok Wong, Ho Pui Ho, Kin Fong Lei, Wen Jung Li, Kwok Sum Chan, Wing Cheung Law, Shu Yuen Wu, Siu Kai Kong, Chinlon Lin

Research output: Chapter in book / Conference proceeding › Conference article published in proceeding or book › Academic research › peer-review

2 Citations (Scopus)

Abstract

The integration between 2D SPR differential phase imaging sensor and microfluidic flow circuit is presented. It provides the advantages of high throughput, high sensitivity and label free detection to meet the present needs in biomechanical market. The differential phase scheme between p- and s- polarization enable elimination of all common-path phase noise while keeping the phase change caused by SPR effect. System sensitivity of the detection sensitivity of our setup is 0.44μg /ml is obtained for salt / water mixture sensing. BSA antigen and antibody binding reaction detection is further demonstrated. The system shows the capability of simultaneous detection for both specific and non-specific binding reactions in a micro-chamber array.

Original language	English
Title of host publication	2005 IEEE Conference on Electron Devices and Solid-State Circuits, EDSSC
Pages	709-712
Number of pages	4
DOIs	https://doi.org/10.1109/EDSSC.2005.1635374
Publication status	Published - 1 Dec 2006
Externally published	Yes
Event	2005 IEEE Conference on Electron Devices and Solid-State Circuits, EDSSC - Howloon, Hong Kong Duration: 19 Dec 2005 → 21 Dec 2005

Conference

Conference	2005 IEEE Conference on Electron Devices and Solid-State Circuits, EDSSC
Country/Territory	Hong Kong
City	Howloon
Period	19/12/05 → 21/12/05

ASJC Scopus subject areas

Electrical and Electronic Engineering
Electronic, Optical and Magnetic Materials

More information

10.1109/EDSSC.2005.1635374

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Wong, C. L., Ho, H. P., Lei, K. F., Li, W. J., Chan, K. S., Law, W. C., Wu, S. Y., Kong, S. K., & Lin, C. (2006). Two dimensional phase sensitive surface plasmon resonance biosensor array using microfluidic flow circuit platform. In 2005 IEEE Conference on Electron Devices and Solid-State Circuits, EDSSC (pp. 709-712). Article 1635374 https://doi.org/10.1109/EDSSC.2005.1635374

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title = "Two dimensional phase sensitive surface plasmon resonance biosensor array using microfluidic flow circuit platform",

abstract = "The integration between 2D SPR differential phase imaging sensor and microfluidic flow circuit is presented. It provides the advantages of high throughput, high sensitivity and label free detection to meet the present needs in biomechanical market. The differential phase scheme between p- and s- polarization enable elimination of all common-path phase noise while keeping the phase change caused by SPR effect. System sensitivity of the detection sensitivity of our setup is 0.44μg /ml is obtained for salt / water mixture sensing. BSA antigen and antibody binding reaction detection is further demonstrated. The system shows the capability of simultaneous detection for both specific and non-specific binding reactions in a micro-chamber array.",

author = "Wong, {Chi Lok} and Ho, {Ho Pui} and Lei, {Kin Fong} and Li, {Wen Jung} and Chan, {Kwok Sum} and Law, {Wing Cheung} and Wu, {Shu Yuen} and Kong, {Siu Kai} and Chinlon Lin",

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month = dec,

day = "1",

doi = "10.1109/EDSSC.2005.1635374",

language = "English",

isbn = "0780393392",

pages = "709--712",

booktitle = "2005 IEEE Conference on Electron Devices and Solid-State Circuits, EDSSC",

note = "2005 IEEE Conference on Electron Devices and Solid-State Circuits, EDSSC ; Conference date: 19-12-2005 Through 21-12-2005",

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Wong, CL, Ho, HP, Lei, KF, Li, WJ, Chan, KS, Law, WC, Wu, SY, Kong, SK & Lin, C 2006, Two dimensional phase sensitive surface plasmon resonance biosensor array using microfluidic flow circuit platform. in 2005 IEEE Conference on Electron Devices and Solid-State Circuits, EDSSC., 1635374, pp. 709-712, 2005 IEEE Conference on Electron Devices and Solid-State Circuits, EDSSC, Howloon, Hong Kong, 19/12/05. https://doi.org/10.1109/EDSSC.2005.1635374

Two dimensional phase sensitive surface plasmon resonance biosensor array using microfluidic flow circuit platform. / Wong, Chi Lok; Ho, Ho Pui; Lei, Kin Fong et al.
2005 IEEE Conference on Electron Devices and Solid-State Circuits, EDSSC. 2006. p. 709-712 1635374.

Research output: Chapter in book / Conference proceeding › Conference article published in proceeding or book › Academic research › peer-review

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Two dimensional phase sensitive surface plasmon resonance biosensor array using microfluidic flow circuit platform

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