Tumor-Triggered Controlled Drug Release from Electrospun Fibers Using Inorganic Caps for Inhibiting Cancer Relapse

Xin Zhao; Ziming Yuan; Lara Yildirimer; Jingwen Zhao; Zhi Yuan Lin; Zhi Cao; Guoqing Pan; Wenguo Cui

doi:10.1002/smll.201500985

Tumor-Triggered Controlled Drug Release from Electrospun Fibers Using Inorganic Caps for Inhibiting Cancer Relapse

Xin Zhao, Ziming Yuan, Lara Yildirimer, Jingwen Zhao, Zhi Yuan Lin, Zhi Cao, Guoqing Pan, Wenguo Cui

Research output: Journal article publication › Journal article › Academic research › peer-review

78 Citations (Scopus)

Abstract

KGaA, Weinheim. A smart, tumor-trigged, controlled drug release using inorganic "caps" with CO₃ ^2- functional groups in electrospun fibers is presented for inhibiting cancer relapse. When the drug-loaded intelligent electrospun fibers encounter pathological acidic environments, the inorganic gates react with the acids and produce CO₂ gas, which enables water penetration into the core of the fibers to induce rapid drug release.

Original language	English
Pages (from-to)	4284-4291
Number of pages	8
Journal	Small
Volume	11
Issue number	34
DOIs	https://doi.org/10.1002/smll.201500985
Publication status	Published - 1 Sept 2015
Externally published	Yes

Keywords

cancer therapy
controlled release
drug delivery, electrospun fibers
inorganic caps
tumor-triggered

ASJC Scopus subject areas

Biotechnology
Biomaterials
Engineering (miscellaneous)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

More information

10.1002/smll.201500985

Cite this

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title = "Tumor-Triggered Controlled Drug Release from Electrospun Fibers Using Inorganic Caps for Inhibiting Cancer Relapse",

abstract = "KGaA, Weinheim. A smart, tumor-trigged, controlled drug release using inorganic {"}caps{"} with CO3 2- functional groups in electrospun fibers is presented for inhibiting cancer relapse. When the drug-loaded intelligent electrospun fibers encounter pathological acidic environments, the inorganic gates react with the acids and produce CO2 gas, which enables water penetration into the core of the fibers to induce rapid drug release.",

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AU - Zhao, Xin

AU - Yuan, Ziming

AU - Yildirimer, Lara

AU - Zhao, Jingwen

AU - Lin, Zhi Yuan

AU - Cao, Zhi

AU - Pan, Guoqing

AU - Cui, Wenguo

PY - 2015/9/1

Y1 - 2015/9/1

N2 - KGaA, Weinheim. A smart, tumor-trigged, controlled drug release using inorganic "caps" with CO3 2- functional groups in electrospun fibers is presented for inhibiting cancer relapse. When the drug-loaded intelligent electrospun fibers encounter pathological acidic environments, the inorganic gates react with the acids and produce CO2 gas, which enables water penetration into the core of the fibers to induce rapid drug release.

AB - KGaA, Weinheim. A smart, tumor-trigged, controlled drug release using inorganic "caps" with CO3 2- functional groups in electrospun fibers is presented for inhibiting cancer relapse. When the drug-loaded intelligent electrospun fibers encounter pathological acidic environments, the inorganic gates react with the acids and produce CO2 gas, which enables water penetration into the core of the fibers to induce rapid drug release.

KW - cancer therapy

KW - controlled release

KW - drug delivery, electrospun fibers

KW - inorganic caps

KW - tumor-triggered

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U2 - 10.1002/smll.201500985

DO - 10.1002/smll.201500985

M3 - Journal article

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VL - 11

SP - 4284

EP - 4291

JO - Small

JF - Small

IS - 34

ER -

Tumor-Triggered Controlled Drug Release from Electrospun Fibers Using Inorganic Caps for Inhibiting Cancer Relapse

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

More information

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