Tumor-Triggered Controlled Drug Release from Electrospun Fibers Using Inorganic Caps for Inhibiting Cancer Relapse

Xin Zhao, Ziming Yuan, Lara Yildirimer, Jingwen Zhao, Zhi Yuan Lin, Zhi Cao, Guoqing Pan, Wenguo Cui

Research output: Journal article publicationJournal articleAcademic researchpeer-review

54 Citations (Scopus)

Abstract

KGaA, Weinheim. A smart, tumor-trigged, controlled drug release using inorganic "caps" with CO3 2- functional groups in electrospun fibers is presented for inhibiting cancer relapse. When the drug-loaded intelligent electrospun fibers encounter pathological acidic environments, the inorganic gates react with the acids and produce CO2 gas, which enables water penetration into the core of the fibers to induce rapid drug release.
Original languageEnglish
Pages (from-to)4284-4291
Number of pages8
JournalSmall
Volume11
Issue number34
DOIs
Publication statusPublished - 1 Sep 2015
Externally publishedYes

Keywords

  • cancer therapy
  • controlled release
  • drug delivery, electrospun fibers
  • inorganic caps
  • tumor-triggered

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Engineering (miscellaneous)

Cite this