Tumor Retention of Nanoscale Gas Vesicles for Molecular Ultrasound Imaging

Guohao Wang, Xuandi Hou, Lin Song, Lei Sun

Research output: Chapter in book / Conference proceedingConference article published in proceeding or bookAcademic researchpeer-review

Abstract

Microbubbles based contrast-enhanced ultrasound plays a more and more important role in oncology1. However, the utility of ultrasound for molecular imaging is significantly limited due to the lack of nanoscale contrast agents that can penetrate through tumor vasculature via the Enhanced Permeability and Retention (EPR)effect2. Recently reported gas vesicles (GVs), isolated from buoyant photosynthetic microbes, demonstrated significant potentials as a novel nanoscale contrast agent for ultrasound molecular imaging3-4. However, the actual capability of GVs to penetrate through EPR and reach tumor site has not been demonstrated. In this research, we evaluated the bio-distribution of GVs in subcutaneous mouse tumor model with in vivo fluorescence imaging and ultrasound imaging, respectively, and studied the GV s biosafety by tissue toxicity assessment.

Original languageEnglish
Title of host publication2018 IEEE International Ultrasonics Symposium, IUS 2018
PublisherIEEE Computer Society
ISBN (Electronic)9781538634257
DOIs
Publication statusPublished - 17 Dec 2018
Event2018 IEEE International Ultrasonics Symposium, IUS 2018 - Kobe, Japan
Duration: 22 Oct 201825 Oct 2018

Publication series

NameIEEE International Ultrasonics Symposium, IUS
Volume2018-October
ISSN (Print)1948-5719
ISSN (Electronic)1948-5727

Conference

Conference2018 IEEE International Ultrasonics Symposium, IUS 2018
Country/TerritoryJapan
CityKobe
Period22/10/1825/10/18

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

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