Transition-metal-catalyzed group transfer reactions for selective C-H bond functionalization of artemisinin

Yungen Liu, Wenbo Xiao, Man Kin Wong, Chi Ming Che

Research output: Journal article publicationJournal articleAcademic researchpeer-review

27 Citations (Scopus)


Three types of novel artemisinin derivatives have been synthesized through transition-metal-catalyzed intramolecular carbenoid and nitrenoid C-H bond insertion reactions. With rhodium complexes as catalysts, lactone 11 was synthesized via carbene insertion reaction at the C16 position in 90% yield; oxazolidinone 13 was synthesized via nitrene insertion reaction at the C10 position in 87% yield based on 77% conversion; and sulfamidate 14 was synthesized via nitrene insertion reaction at the C8 position in 87% yield.
Original languageEnglish
Pages (from-to)4107-4110
Number of pages4
JournalOrganic Letters
Issue number21
Publication statusPublished - 11 Oct 2007
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine

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