Abstract
Cardiac-synchronized brain motion is well documented, but the accurate measurement of such motion on the pixel-by-pixel basis has been hampered by the lack of proper imaging technique. In this article, the authors present the implementation of an autotracking spiral cine displacement-encoded stimulation echo (DENSE) magnetic resonance imaging (MRI) technique for the measurement of pulsatile brain motion during the cardiac cycle. Displacement-encoded dynamic MR images of three healthy volunteers were acquired throughout the cardiac cycle using the spiral cine-DENSE pulse sequence gated to the R wave of an electrocardiogram. Pixelwise Lagrangian displacement maps were computed, and 2D displacement as a function of time was determined for selected regions of interests. Different intracranial structures exhibited characteristic motion amplitude, direction, and pattern throughout the cardiac cycle. Time-resolved displacement curves revealed the pathway of pulsatile motion from brain stem to peripheral brain lobes. These preliminary results demonstrated that the spiral cine-DENSE MRI technique can be used to measure cardiac-synchronized pulsatile brain motion on the pixel-by-pixel basis with high temporal/spatial resolution and sensitivity.
Original language | English |
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Pages (from-to) | 3413-3419 |
Number of pages | 7 |
Journal | Medical Physics |
Volume | 36 |
Issue number | 8 |
DOIs | |
Publication status | Published - 1 Jan 2009 |
Externally published | Yes |
Keywords
- Brain motion
- DENSE
- MRI
- Stereotactic radiosurgery
ASJC Scopus subject areas
- Biophysics
- Radiology Nuclear Medicine and imaging