Trabecular Bone Status in Ultradistal Tibia Under Habitual Gait Loading: A pQCT Study in Postmenopausal Women

Yau Ming Lai, Ling Qin, Vivian Wing Yin Hung, Wing Yee Choy, Suk Tak Chan, Wing Chi Chan, Kai Ming Chan

Research output: Journal article publicationJournal articleAcademic researchpeer-review

6 Citations (Scopus)


This study investigated regional volumetric trabecular bone mineral density (tBMD) and bone area at the ultradistal tibia in Chinese women using peripheral quantitative computed tomography. Fifty-six postmenopausal women aged 47-62 yr participated in BMD measurements at baseline and 22 of them were followed at both 1-yr and 3-yr follow-up scans. Regional baseline tBMD, rate of annual bone loss, and trabecular bone area were determined. Baseline measurements showed that the tBMD of both the posterior (252.9 ± 63.4 mg/cm3) and medial (226.6 ± 68.9 mg/cm3) regions was significantly higher than that of the anterior (126.3 ± 61.9 mg/cm3) and lateral regions (149.8 ± 50.6 mg/cm3), respectively (p < 0.001). Both the 1-yr and 3-yr follow-up measurements showed that there was significant physiological annual tBMD loss on an average of 1.61%, at the four regions. Inter-slice regional tBMD and trabecular bone area measurements demonstrated a significant linear decrease from the distal to proximal aspects (p < 0.001). Findings suggest that dynamic compressive loading during the heel strike and the body weight vector shifting toward the medial aspect during the stance phase in a normal gait might account for the regional tBMD differences. Increased tBMD and bone area toward the distal tibial endplate may adapt to withstand the axial impact loading. However, the low-impact weight-bearing nature of a normal gait may not be osteogenic to prevent regional bone loss. An exercise program specific to the women at risk should be contemplated.
Original languageEnglish
Pages (from-to)175-183
Number of pages9
JournalJournal of Clinical Densitometry
Issue number2
Publication statusPublished - 1 Apr 2006


  • Bone loss
  • mechanical adaptation
  • postmenopausal women
  • trabecular bone mineral density

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine
  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Trabecular Bone Status in Ultradistal Tibia Under Habitual Gait Loading: A pQCT Study in Postmenopausal Women'. Together they form a unique fingerprint.

Cite this