TY - JOUR
T1 - Toxicoproteomic assessment of liver responses to acute pyrrolizidine alkaloid intoxication in rats
AU - Li, Yan Hong
AU - Tai, William Chi Shing
AU - Khan, Imran
AU - Lu, Cheng
AU - Lu, Yao
AU - Wong, Wing Yan
AU - Chan, Wood Yee
AU - Wendy Hsiao, Wen Luan
AU - Lin, Ge
PY - 2018/4/3
Y1 - 2018/4/3
N2 - A toxicoproteomic study was performed on liver of rats treated with retrorsine (RTS), a representative hepatotoxic pyrrolizidine alkaloid at a toxic dose (140 mg/kg) known to cause severe acute hepatotoxicity. By comparing current data with our previous findings in mild liver lesions of rats treated with a lower dose of RTS, seven proteins and three toxicity pathways of vascular endothelial cell death, which was further verified by observed sinusoidal endothelial cell losses, were found uniquely associated with retrorsine-induced hepatotoxicity. This toxicoproteomic study of acute pyrrolizidine alkaloid intoxication lays a foundation for future investigation to delineate molecular mechanisms of pyrrolizidine alkaloid-induced hepatotoxicity.
AB - A toxicoproteomic study was performed on liver of rats treated with retrorsine (RTS), a representative hepatotoxic pyrrolizidine alkaloid at a toxic dose (140 mg/kg) known to cause severe acute hepatotoxicity. By comparing current data with our previous findings in mild liver lesions of rats treated with a lower dose of RTS, seven proteins and three toxicity pathways of vascular endothelial cell death, which was further verified by observed sinusoidal endothelial cell losses, were found uniquely associated with retrorsine-induced hepatotoxicity. This toxicoproteomic study of acute pyrrolizidine alkaloid intoxication lays a foundation for future investigation to delineate molecular mechanisms of pyrrolizidine alkaloid-induced hepatotoxicity.
KW - Acute hepatotoxicity
KW - pyrrolizidine alkaloids
KW - retrorsine
KW - toxicoproteomics
UR - http://www.scopus.com/inward/record.url?scp=85045724137&partnerID=8YFLogxK
U2 - 10.1080/10590501.2018.1450186
DO - 10.1080/10590501.2018.1450186
M3 - Journal article
C2 - 29667502
AN - SCOPUS:85045724137
SN - 1059-0501
VL - 36
SP - 65
EP - 83
JO - Journal of Environmental Science and Health - Part C Environmental Carcinogenesis and Ecotoxicology Reviews
JF - Journal of Environmental Science and Health - Part C Environmental Carcinogenesis and Ecotoxicology Reviews
IS - 2
ER -
