Toxicoproteomic assessment of liver responses to acute pyrrolizidine alkaloid intoxication in rats

Yan Hong Li, William Chi Shing Tai, Imran Khan, Cheng Lu, Yao Lu, Wing Yan Wong, Wood Yee Chan, Wen Luan Wendy Hsiao, Ge Lin

Research output: Journal article publicationJournal articleAcademic researchpeer-review

11 Citations (Scopus)

Abstract

A toxicoproteomic study was performed on liver of rats treated with retrorsine (RTS), a representative hepatotoxic pyrrolizidine alkaloid at a toxic dose (140 mg/kg) known to cause severe acute hepatotoxicity. By comparing current data with our previous findings in mild liver lesions of rats treated with a lower dose of RTS, seven proteins and three toxicity pathways of vascular endothelial cell death, which was further verified by observed sinusoidal endothelial cell losses, were found uniquely associated with retrorsine-induced hepatotoxicity. This toxicoproteomic study of acute pyrrolizidine alkaloid intoxication lays a foundation for future investigation to delineate molecular mechanisms of pyrrolizidine alkaloid-induced hepatotoxicity.

Original languageEnglish
Pages (from-to)65-83
Number of pages19
JournalJournal of Environmental Science and Health - Part C Environmental Carcinogenesis and Ecotoxicology Reviews
Volume36
Issue number2
DOIs
Publication statusPublished - 3 Apr 2018

Keywords

  • Acute hepatotoxicity
  • pyrrolizidine alkaloids
  • retrorsine
  • toxicoproteomics

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Cancer Research

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