Abstract
A toxicoproteomic study was performed on liver of rats treated with retrorsine (RTS), a representative hepatotoxic pyrrolizidine alkaloid at a toxic dose (140 mg/kg) known to cause severe acute hepatotoxicity. By comparing current data with our previous findings in mild liver lesions of rats treated with a lower dose of RTS, seven proteins and three toxicity pathways of vascular endothelial cell death, which was further verified by observed sinusoidal endothelial cell losses, were found uniquely associated with retrorsine-induced hepatotoxicity. This toxicoproteomic study of acute pyrrolizidine alkaloid intoxication lays a foundation for future investigation to delineate molecular mechanisms of pyrrolizidine alkaloid-induced hepatotoxicity.
Original language | English |
---|---|
Pages (from-to) | 65-83 |
Number of pages | 19 |
Journal | Journal of Environmental Science and Health - Part C Environmental Carcinogenesis and Ecotoxicology Reviews |
Volume | 36 |
Issue number | 2 |
DOIs | |
Publication status | Published - 3 Apr 2018 |
Keywords
- Acute hepatotoxicity
- pyrrolizidine alkaloids
- retrorsine
- toxicoproteomics
ASJC Scopus subject areas
- Health, Toxicology and Mutagenesis
- Cancer Research