Total synthesis of teixobactin

Kang Jin; Iek Hou Sam; Kathy Hiu Laam Po; Du'An Lin; Ebrahim H. Ghazvini Zadeh; Sheng Chen; Yu Yuan; Xuechen Li

doi:10.1038/ncomms12394

Total synthesis of teixobactin

Kang Jin, Iek Hou Sam, Kathy Hiu Laam Po, Du'An Lin, Ebrahim H. Ghazvini Zadeh, Sheng Chen, Yu Yuan, Xuechen Li

Research output: Journal article publication › Journal article › Academic research › peer-review

107 Citations (Scopus)

Abstract

To cope with the global bacterial multidrug resistance, scientific communities have devoted significant efforts to develop novel antibiotics, particularly those with new modes of actions. Teixobactin, recently isolated from uncultured bacteria, is considered as a promising first-in-class drug candidate for clinical development. Herein, we report its total synthesis by a highly convergent Ser ligation approach and this strategy allows us to prepare several analogues of the natural product.

Original language	English
Article number	12394
Journal	Nature Communications
Volume	7
DOIs	https://doi.org/10.1038/ncomms12394
Publication status	Published - 3 Aug 2016

ASJC Scopus subject areas

General Chemistry
General Biochemistry,Genetics and Molecular Biology
General Physics and Astronomy

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10.1038/ncomms12394

http://hdl.handle.net/10397/62032

Cite this

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AU - Chen, Sheng

AU - Yuan, Yu

AU - Li, Xuechen

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Total synthesis of teixobactin

Abstract

ASJC Scopus subject areas

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