Total synthesis of teixobactin

Kang Jin, Iek Hou Sam, Kathy Hiu Laam Po, Du'An Lin, Ebrahim H. Ghazvini Zadeh, Sheng Chen, Yu Yuan, Xuechen Li

Research output: Journal article publicationJournal articleAcademic researchpeer-review

77 Citations (Scopus)

Abstract

To cope with the global bacterial multidrug resistance, scientific communities have devoted significant efforts to develop novel antibiotics, particularly those with new modes of actions. Teixobactin, recently isolated from uncultured bacteria, is considered as a promising first-in-class drug candidate for clinical development. Herein, we report its total synthesis by a highly convergent Ser ligation approach and this strategy allows us to prepare several analogues of the natural product.
Original languageEnglish
Article number12394
JournalNature Communications
Volume7
DOIs
Publication statusPublished - 3 Aug 2016

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

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