Topographical Control of Preosteoblast Culture by Shape Memory Foams

Ruiqi Xie, Jinlian Hu, Xia Guo, Frankie Ng, Tingwu Qin

Research output: Journal article publicationJournal articleAcademic researchpeer-review

8 Citations (Scopus)

Abstract

KGaA, Weinheim Here, the authors present a thermo-responsive shape memory polymer (SMP) foam that can be programmed to control the preosteoblast behavior by changing porous architecture during cell cultivation. The preosteoblast cells are seeded on the SMP foams with temporarily compressed pore structure. Results show that cells preferentially align along the pore length direction. After the pore recovery at 37 °C, cells remain attached and viable but change their topography in a tangential direction along the pore edge. This work indicates the shape-memory actuated porous structure in SMP foam can control the cell behavior. This may provide an effective method for studying cell responses to dynamic environment and facilitate the healthy and optimal development of tissue engineering.
Original languageEnglish
Article number1600343
JournalAdvanced Engineering Materials
Volume19
Issue number1
DOIs
Publication statusPublished - 1 Jan 2017

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics

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