Abstract
Purpose : To study the effects and the underlying mechanism of latanoprost on induced myopia in chicken
Methods : Myopia was induced in the right eyes of chicks using diffuser lenses (FDM) or -10D single vision lenses (LIM) for 12 days, while the left eyes were untreated control. One drop of topical latanoprost 0.005% or saline was administered daily in the treated and control groups, respectively. Refractive errors, tonometry and high-frequency A-scan ultrasonography were measured on days 0, 4, 8 and 12. Eyeballs were enucleated and processed for hematoxylin & eosin staining and western blot respectively. A total of 40 chicks were randomly divided into four groups (n=10). Data are presented as mean interocular differences ± standard deviation (SD).
Results : After 12 days of treatment, latanoprost inhibited both FDM and LIM. FDM control: -16.02±2.80D vs FDM latanoprost: -10.86±2.54D, p
Conclusions : Topical latanoprost inhibit FDM and LIM in the chicken model and its effect was associated with a reduced IOP and upregulated Egr1 protein expression.
Methods : Myopia was induced in the right eyes of chicks using diffuser lenses (FDM) or -10D single vision lenses (LIM) for 12 days, while the left eyes were untreated control. One drop of topical latanoprost 0.005% or saline was administered daily in the treated and control groups, respectively. Refractive errors, tonometry and high-frequency A-scan ultrasonography were measured on days 0, 4, 8 and 12. Eyeballs were enucleated and processed for hematoxylin & eosin staining and western blot respectively. A total of 40 chicks were randomly divided into four groups (n=10). Data are presented as mean interocular differences ± standard deviation (SD).
Results : After 12 days of treatment, latanoprost inhibited both FDM and LIM. FDM control: -16.02±2.80D vs FDM latanoprost: -10.86±2.54D, p
Conclusions : Topical latanoprost inhibit FDM and LIM in the chicken model and its effect was associated with a reduced IOP and upregulated Egr1 protein expression.
| Original language | English |
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| Title of host publication | Investigative Ophthalmology & Visual Science |
| Pages | 1882 |
| Volume | 63 |
| ISBN (Electronic) | 1552-5783 |
| Publication status | Published - Jun 2022 |
| Event | Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting 2022 - Denver, United States Duration: 1 May 2022 → 4 May 2022 |
Conference
| Conference | Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting 2022 |
|---|---|
| Abbreviated title | ARVO 2022 |
| Country/Territory | United States |
| City | Denver |
| Period | 1/05/22 → 4/05/22 |