Topical delivery of silver nanoparticles promotes wound healing

Jun Tian, Kenneth K.Y. Wong, Chi Ming Ho, Chun Nam Lok, Wing Yiu Yu, Chi Ming Che, Jen Fu Chiu, Paul K.H. Tam

Research output: Journal article publicationJournal articleAcademic researchpeer-review

597 Citations (Scopus)

Abstract

Wound healing is a complex process and has been the subject of intense research for a long time. The recent emergence of nanotechnology has provided a new therapeutic modality in silver nanoparticles for use in burn wounds. Nonetheless, the beneficial effects of silver nanoparticles on wound healing remain unknown. We investigated the wound-healing properties of silver nanoparticles in an animal model and found that rapid healing and improved cosmetic appearance occur in a dose-dependent manner. Furthermore, through quantitative PCR, immunohistochemistry, and proteomic studies, we showed that silver nanoparticles exert positive effects through their antimicrobial properties, reduction in wound inflammation, and modulation of fibrogenic cytokines. These results have given insight into the actions of silver and have provided a novel therapeutic direction for wound treatment in clinical practice. KGaA.
Original languageEnglish
Pages (from-to)129-136
Number of pages8
JournalChemMedChem
Volume2
Issue number1
DOIs
Publication statusPublished - 15 Jan 2007
Externally publishedYes

Keywords

  • Cytokines
  • Medicinal chemistry
  • Nanostructures
  • Proteomics
  • Silver
  • Wound healing

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Organic Chemistry

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