Time-reversed magnetically controlled perturbation (TRMCP) optical focusing inside scattering media

Zhipeng Yu, Jiangtao Huangfu, Fangyuan Zhao, Meiyun Xia, Xi Wu, Xufeng Niu, Deyu Li, Puxiang Lai (Corresponding Author), Daifa Wang (Corresponding Author)

Research output: Journal article publicationReview articleAcademic researchpeer-review

30 Citations (Scopus)


Manipulating and focusing light deep inside biological tissue and tissue-like complex media has been desired for long yet considered challenging. One feasible strategy is through optical wavefront engineering, where the optical scattering-induced phase distortions are time reversed or pre-compensated so that photons travel along different optical paths interfere constructively at the targeted position within a scattering medium. To define the targeted position, an internal guidestar is needed to guide or provide a feedback for wavefront engineering. It could be injected or embedded probes such as fluorescence or nonlinear microspheres, ultrasonic modulation, as well as absorption perturbation. Here we propose to use a magnetically controlled optical absorbing microsphere as the internal guidestar. Using a digital optical phase conjugation system, we obtained sharp optical focusing within scattering media through time-reversing the scattered light perturbed by the magnetic microsphere. Since the object is magnetically controlled, dynamic optical focusing is allowed with a relatively large field-of-view by scanning the magnetic field externally. Moreover, the magnetic microsphere can be packaged with an organic membrane, using biological or chemical means to serve as a carrier. Therefore, the technique may find particular applications for enhanced targeted drug delivery, and imaging and photoablation of angiogenic vessels in tumours.
Original languageEnglish
Article number2927
JournalScientific Reports
Issue number1
Publication statusPublished - 1 Dec 2018

ASJC Scopus subject areas

  • General


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