Time-resolved spectroscopy studies of the photodeprotection reactions of p-hydroxyphenacyl ester phototrigger compounds

Chensheng Ma, Wai Ming Kwok, Wing Sum Chan, Yong Du, Peng Zuo, Jovi Tze Wai Kan, Patrick H. Toy, David Lee Phillips

Research output: Journal article publicationJournal articleAcademic researchpeer-review

4 Citations (Scopus)

Abstract

Ultrafast time-resolved spectroscopy and time-resolved resonance Raman spectroscopy experimental results in the picoseocond timescales are reported for selected p-hydroxyphenacyl (pHP) ester phototrigger compounds. The results better elucidate the photodeprotection and rearrangement reactions of these important phototriggers and an overall mechanism is proposed for these reactions based on the time-resolved spectroscopy data presented here. This work indicates that site-specific, concerted solvation of the hydroxy proton and phosphate-leaving anion group through their respective intermolecular H-bonding with solvent water molecules promotes the photodeprotection reaction.
Original languageEnglish
Pages (from-to)202-209
Number of pages8
JournalCurrent Science
Volume97
Issue number2
Publication statusPublished - 1 Jul 2009
Externally publishedYes

Keywords

  • P-hydroxyphenacyl cage
  • Phototriggers
  • Raman spectroscopy
  • Time-resolved resonance
  • Ultrafast spectroscopy

ASJC Scopus subject areas

  • General

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