TY - JOUR
T1 - Time-evolving coupling functions for evaluating the interaction between cerebral oxyhemoglobin and arterial blood pressure with hypertension
AU - Li, Wenhao
AU - Zhang, Ming
AU - Huo, Congcong
AU - Xu, Gongcheng
AU - Chen, Wei
AU - Wang, Daifa
AU - Li, Zengyong
N1 - Funding Information:
This project was supported by the National Key Research and Development Project (2020YFC2004200)，National Natural Science Foundation of China (Grant No. 31771071, 11732015, 61675013), Fundamental Research Funds for Central Public Welfare Research Institutes (118009001000160001) and Key Research and Development Project of Jiangxi Province (20202BBGL73057).
Publisher Copyright:
© 2020 American Association of Physicists in Medicine
PY - 2021/4
Y1 - 2021/4
N2 - Purposes: This study aimed to investigate the network coupling between arterial blood pressure (ABP) and changes in cerebral oxyhemoglobin concentration (Δ [O2Hb]/Δ [HHb]) oscillations based on dynamical Bayesian inference in hypertensive subjects. Methods: Two groups of subjects, consisting of 30 healthy (Group Control, 55.1 ± 10.6 y), and 32 hypertensive individuals (Group AH, 58.9 ± 8.7 y), participated in this study. A functional near-infrared spectroscopy system was used to measure the Δ [O2Hb] and Δ [HHb] signals in the bilateral prefrontal cortex (LPFC/RPFC), motor cortex (LMC/RMC), and occipital lobe (LOL/ROL) during the resting state (12 min). Based on continuous wavelet analysis and coupling functions, the directed coupling strength (CS) between ABP and cerebral hemoglobin was identified and analyzed in three frequency intervals (I: 0.6–2 Hz, II: 0.145–0.6 Hz, III: 0.01–0.08 Hz). The Pearson correlations between the CS and blood pressure parameters were calculated in the hypertension group. Results: In interval I, Group AH exhibited a significantly higher CS for the coupling from ABP to Δ [O2Hb] than Group Control in LMC, RMC, LOL, and ROL. In interval III, the CS from ABP to Δ [O2Hb] in LPFC, RPFC, LMC, RMC, LOL, and ROL was significantly higher in Group AH than in Group Control. For the patients with hypertension, diastolic blood pressure was negatively and pulse pressure was positively related to the CS from ABP to Δ [O2Hb] oscillations in interval III. Conclusions: The higher CS from ABP to Δ [O2Hb] in interval I indicated that the components of cardiac activity in cerebral hemoglobin oscillations were more directly responsive to the changes in systematic ABP in patients with hypertension than in healthy subjects. Meanwhile, the higher CS from ABP to Δ [O2Hb] in interval III indicated that the cerebral hemoglobin oscillations were susceptible to changes in blood pressure in hypertensive subjects. The results may serve as evidence of impairment in cerebral autoregulation after hypertension. The Pearson correlation results showed that diastolic blood pressure and pulse pressure might be regarded as predictors of cerebral autoregulation function in patients with hypertension, and may be useful for hypertension stratification. This study provides novel insights into the interaction mechanism between ABP and cerebral hemodynamics and could help in the development of new assessment techniques for cerebral vascular disease.
AB - Purposes: This study aimed to investigate the network coupling between arterial blood pressure (ABP) and changes in cerebral oxyhemoglobin concentration (Δ [O2Hb]/Δ [HHb]) oscillations based on dynamical Bayesian inference in hypertensive subjects. Methods: Two groups of subjects, consisting of 30 healthy (Group Control, 55.1 ± 10.6 y), and 32 hypertensive individuals (Group AH, 58.9 ± 8.7 y), participated in this study. A functional near-infrared spectroscopy system was used to measure the Δ [O2Hb] and Δ [HHb] signals in the bilateral prefrontal cortex (LPFC/RPFC), motor cortex (LMC/RMC), and occipital lobe (LOL/ROL) during the resting state (12 min). Based on continuous wavelet analysis and coupling functions, the directed coupling strength (CS) between ABP and cerebral hemoglobin was identified and analyzed in three frequency intervals (I: 0.6–2 Hz, II: 0.145–0.6 Hz, III: 0.01–0.08 Hz). The Pearson correlations between the CS and blood pressure parameters were calculated in the hypertension group. Results: In interval I, Group AH exhibited a significantly higher CS for the coupling from ABP to Δ [O2Hb] than Group Control in LMC, RMC, LOL, and ROL. In interval III, the CS from ABP to Δ [O2Hb] in LPFC, RPFC, LMC, RMC, LOL, and ROL was significantly higher in Group AH than in Group Control. For the patients with hypertension, diastolic blood pressure was negatively and pulse pressure was positively related to the CS from ABP to Δ [O2Hb] oscillations in interval III. Conclusions: The higher CS from ABP to Δ [O2Hb] in interval I indicated that the components of cardiac activity in cerebral hemoglobin oscillations were more directly responsive to the changes in systematic ABP in patients with hypertension than in healthy subjects. Meanwhile, the higher CS from ABP to Δ [O2Hb] in interval III indicated that the cerebral hemoglobin oscillations were susceptible to changes in blood pressure in hypertensive subjects. The results may serve as evidence of impairment in cerebral autoregulation after hypertension. The Pearson correlation results showed that diastolic blood pressure and pulse pressure might be regarded as predictors of cerebral autoregulation function in patients with hypertension, and may be useful for hypertension stratification. This study provides novel insights into the interaction mechanism between ABP and cerebral hemodynamics and could help in the development of new assessment techniques for cerebral vascular disease.
KW - arterial blood pressure
KW - cerebral hemodynamics
KW - dynamical Bayesian inference
KW - hypertension
UR - http://www.scopus.com/inward/record.url?scp=85104536540&partnerID=8YFLogxK
U2 - 10.1002/mp.14627
DO - 10.1002/mp.14627
M3 - Journal article
C2 - 33253413
AN - SCOPUS:85104536540
SN - 0094-2405
VL - 48
SP - 2027
EP - 2037
JO - Medical Physics
JF - Medical Physics
IS - 4
ER -