Three-Dimensional Elastography for Cervical Lymph Node Volume Measurements: A Study to Investigate Feasibility, Accuracy and Reliability

Tin Cheung Ying, Yongping Zheng, Brian Chin Wing Kot, James Chung Wai Cheung, Sammy Chi Him Cheng, Dora Lai Wan Kwong

Research output: Journal article publicationJournal articleAcademic researchpeer-review

5 Citations (Scopus)


This study investigated the feasibility of using three-dimensional (3-D) elastography in measuring cervical lymph node volume and compared the accuracy and reliability of 3-D elastography and 3-D grayscale ultrasound in measurement of ill-defined cervical nodes. Eighteen porcine lymph nodes from the neck were embedded in tissue-mimicking phantoms and scanned with the two ultrasound techniques. Ultrasound measurements were compared with the volume determined by water-displacement method to evaluate measurement accuracy. Inter-observer reproducibility and intra-observer repeatability of measurements were evaluated. Four patients with enlarged neck nodes were included to evaluate intra-observer repeatability of ultrasound measurements. Results demonstrated that lymph nodes that appeared ill-defined on grayscale ultrasound showed well-defined boundaries on elastography. 3-D elastography has higher measurement accuracy (84.2%), reproducibility (intraclass correlation coefficient, ICC = 0.909) and repeatability (ICC = 0.964-0.988) than does 3-D grayscale ultrasound (62.2%, 0.777 and 0.863-0.906 respectively). As a conclusion, 3-D elastography is accurate and reliable in volume measurement of ill-defined lymph nodes and has potential for accurate assessment of lymph node volume.
Original languageEnglish
Pages (from-to)396-406
Number of pages11
JournalUltrasound in Medicine and Biology
Issue number3
Publication statusPublished - 1 Jan 2013


  • Elastography
  • Lymph node
  • Three-dimensional imaging
  • Ultrasound

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Biophysics
  • Radiology Nuclear Medicine and imaging


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