Thermal and Photo Dual-Responsive Core-Shell Polymeric Nanocarriers with Encapsulation of Upconversion Nanoparticles for Controlled Anticancer Drug Release

Xiaotao Wang; Chuang Liu; Zhenhua Li; Chak Yin Tang; Wing Cheung Law; Xinghou Gong; Zuifang Liu; Yonggui Liao; Gaowen Zhang; Shijun Long; Ling Chen

doi:10.1021/acs.jpcc.9b00454

Thermal and Photo Dual-Responsive Core-Shell Polymeric Nanocarriers with Encapsulation of Upconversion Nanoparticles for Controlled Anticancer Drug Release

Xiaotao Wang
, Chuang Liu
, Zhenhua Li
, Chak Yin Tang
, Wing Cheung Law
, Xinghou Gong
, Zuifang Liu
, Yonggui Liao
, Gaowen Zhang
, Shijun Long
, Ling Chen

Research output: Journal article publication › Journal article › Academic research › peer-review

29 Citations (Scopus)

Abstract

A thermal and photo dual-responsive drug delivery system is newly designed for controlled anticancer drug delivery. The concept of this design is to encapsulate upconversion nanoparticles in a photoresponsive polymer to produce core-shell nanoparticles, in which NIR light is converted to UV/visible light to isomerize cross-linked bis(methacryloylamino)-azobenzene for the control of drug release. A facile scheme, which gives the details of two-step solvothermal treatment, microemulsion, distillation precipitation polymerization, and drug loading, is proposed to realize the design. The dual-responsive drug release behaviors of the system are reported to provide the information for potential development of cancer therapy. It is also found that the Baker-Lonsdale model is suitable for describing the drug release kinetics of this system and the values of the diffusion coefficient under various conditions are determined experimentally.

Original language	English
Pages (from-to)	10658-10665
Number of pages	8
Journal	Journal of Physical Chemistry C
Volume	123
Issue number	16
DOIs	https://doi.org/10.1021/acs.jpcc.9b00454
Publication status	Published - 25 Apr 2019

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
General Energy
Physical and Theoretical Chemistry
Surfaces, Coatings and Films

More information

10.1021/acs.jpcc.9b00454

http://hdl.handle.net/10397/104444

Cite this

Wang, X., Liu, C., Li, Z., Tang, C. Y., Law, W. C., Gong, X., Liu, Z., Liao, Y., Zhang, G., Long, S., & Chen, L. (2019). Thermal and Photo Dual-Responsive Core-Shell Polymeric Nanocarriers with Encapsulation of Upconversion Nanoparticles for Controlled Anticancer Drug Release. Journal of Physical Chemistry C, 123(16), 10658-10665. https://doi.org/10.1021/acs.jpcc.9b00454

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abstract = "A thermal and photo dual-responsive drug delivery system is newly designed for controlled anticancer drug delivery. The concept of this design is to encapsulate upconversion nanoparticles in a photoresponsive polymer to produce core-shell nanoparticles, in which NIR light is converted to UV/visible light to isomerize cross-linked bis(methacryloylamino)-azobenzene for the control of drug release. A facile scheme, which gives the details of two-step solvothermal treatment, microemulsion, distillation precipitation polymerization, and drug loading, is proposed to realize the design. The dual-responsive drug release behaviors of the system are reported to provide the information for potential development of cancer therapy. It is also found that the Baker-Lonsdale model is suitable for describing the drug release kinetics of this system and the values of the diffusion coefficient under various conditions are determined experimentally.",

author = "Xiaotao Wang and Chuang Liu and Zhenhua Li and Tang, \{Chak Yin\} and Law, \{Wing Cheung\} and Xinghou Gong and Zuifang Liu and Yonggui Liao and Gaowen Zhang and Shijun Long and Ling Chen",

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Wang, X, Liu, C, Li, Z, Tang, CY , Law, WC, Gong, X, Liu, Z, Liao, Y, Zhang, G, Long, S & Chen, L 2019, 'Thermal and Photo Dual-Responsive Core-Shell Polymeric Nanocarriers with Encapsulation of Upconversion Nanoparticles for Controlled Anticancer Drug Release', Journal of Physical Chemistry C, vol. 123, no. 16, pp. 10658-10665. https://doi.org/10.1021/acs.jpcc.9b00454

Thermal and Photo Dual-Responsive Core-Shell Polymeric Nanocarriers with Encapsulation of Upconversion Nanoparticles for Controlled Anticancer Drug Release. / Wang, Xiaotao; Liu, Chuang; Li, Zhenhua et al.
In: Journal of Physical Chemistry C, Vol. 123, No. 16, 25.04.2019, p. 10658-10665.

Research output: Journal article publication › Journal article › Academic research › peer-review

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AU - Wang, Xiaotao

AU - Liu, Chuang

AU - Li, Zhenhua

AU - Tang, Chak Yin

AU - Law, Wing Cheung

AU - Gong, Xinghou

AU - Liu, Zuifang

AU - Liao, Yonggui

AU - Zhang, Gaowen

AU - Long, Shijun

AU - Chen, Ling

PY - 2019/4/25

Y1 - 2019/4/25

N2 - A thermal and photo dual-responsive drug delivery system is newly designed for controlled anticancer drug delivery. The concept of this design is to encapsulate upconversion nanoparticles in a photoresponsive polymer to produce core-shell nanoparticles, in which NIR light is converted to UV/visible light to isomerize cross-linked bis(methacryloylamino)-azobenzene for the control of drug release. A facile scheme, which gives the details of two-step solvothermal treatment, microemulsion, distillation precipitation polymerization, and drug loading, is proposed to realize the design. The dual-responsive drug release behaviors of the system are reported to provide the information for potential development of cancer therapy. It is also found that the Baker-Lonsdale model is suitable for describing the drug release kinetics of this system and the values of the diffusion coefficient under various conditions are determined experimentally.

AB - A thermal and photo dual-responsive drug delivery system is newly designed for controlled anticancer drug delivery. The concept of this design is to encapsulate upconversion nanoparticles in a photoresponsive polymer to produce core-shell nanoparticles, in which NIR light is converted to UV/visible light to isomerize cross-linked bis(methacryloylamino)-azobenzene for the control of drug release. A facile scheme, which gives the details of two-step solvothermal treatment, microemulsion, distillation precipitation polymerization, and drug loading, is proposed to realize the design. The dual-responsive drug release behaviors of the system are reported to provide the information for potential development of cancer therapy. It is also found that the Baker-Lonsdale model is suitable for describing the drug release kinetics of this system and the values of the diffusion coefficient under various conditions are determined experimentally.

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Thermal and Photo Dual-Responsive Core-Shell Polymeric Nanocarriers with Encapsulation of Upconversion Nanoparticles for Controlled Anticancer Drug Release

Abstract

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ASJC Scopus subject areas

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