TY - JOUR
T1 - Therapeutic options of TCM for organ injuries associated with COVID-19 and the underlying mechanism
AU - Zhang, Jia Li
AU - Li, Wen Xiong
AU - Li, Yue
AU - Wong, Man Sau
AU - Wang, Yong Jun
AU - Zhang, Yan
N1 - Funding Information:
This work was supported in part by Essential Drug Research and Development (2019ZX09201004-003-032) and National Key R&D Program (2018YFC1704302) from Ministry of Science and Technology of China, Hundred Talents Program from Shanghai Municipal Health Commission (2018BR03), Program of Shanghai Academic Research Leader ( 19XD1423800 ), and Three Years Action to Accelerate the Development of Traditional Chinese Medicine Plan (ZY(2018-2020)-CCCX-3003).
Publisher Copyright:
© 2020 Elsevier GmbH
PY - 2021/5
Y1 - 2021/5
N2 - Background: Coronavirus disease-2019 (COVID-19) caused by infection with severe acute respiratory coronavirus-2 (SARS-CoV-2) has been spreading rapidly throughout China and in other countries since the end of 2019. The World Health Organization (WHO) has declared that the epidemic is a public health emergency of international concerns. The timely and appropriate measures for treating COVID-19 in China, which are inseparable from the contribution of traditional Chinese medicine (TCM), have won much praise of the world. Purpose: This review aimed to summarize and discuss the essential role of TCM in protecting tissues from injuries associated with COVID-19, and accordingly to clarify the possible action mechanisms of TCM from the perspectives of anti-inflammatory, antioxidant and anti-apoptotic effects. Methods: Electronic databases such as Pubmed, ResearchGate, Science Direct, Web of Science, medRixv and Wiley were used to search scientific literatures. Results: The present review found that traditional Chinese herbs commonly used for the clinical treatment of organ damages caused by COVID-19, such as Scutellaria baicalensis, Salvia miltiorrhizaSalvia miltiorrhiza, and ginseng, could act on multiple signaling pathways involved in inflammation, oxidative stress and apoptosis. Conclusion: TCM could protect COVID-19 patients from tissue injuries, a protection that might be, at least partially, attributed to the anti-inflammatory, antioxidant and anti-apoptotic effects of the TCM under investigation. This review provides evidence and support for clinical treatment and novel drug research using TCM.
AB - Background: Coronavirus disease-2019 (COVID-19) caused by infection with severe acute respiratory coronavirus-2 (SARS-CoV-2) has been spreading rapidly throughout China and in other countries since the end of 2019. The World Health Organization (WHO) has declared that the epidemic is a public health emergency of international concerns. The timely and appropriate measures for treating COVID-19 in China, which are inseparable from the contribution of traditional Chinese medicine (TCM), have won much praise of the world. Purpose: This review aimed to summarize and discuss the essential role of TCM in protecting tissues from injuries associated with COVID-19, and accordingly to clarify the possible action mechanisms of TCM from the perspectives of anti-inflammatory, antioxidant and anti-apoptotic effects. Methods: Electronic databases such as Pubmed, ResearchGate, Science Direct, Web of Science, medRixv and Wiley were used to search scientific literatures. Results: The present review found that traditional Chinese herbs commonly used for the clinical treatment of organ damages caused by COVID-19, such as Scutellaria baicalensis, Salvia miltiorrhizaSalvia miltiorrhiza, and ginseng, could act on multiple signaling pathways involved in inflammation, oxidative stress and apoptosis. Conclusion: TCM could protect COVID-19 patients from tissue injuries, a protection that might be, at least partially, attributed to the anti-inflammatory, antioxidant and anti-apoptotic effects of the TCM under investigation. This review provides evidence and support for clinical treatment and novel drug research using TCM.
KW - Active component
KW - Coronavirus disease 2019
KW - Pharmacological mechanism
KW - Severe acute respiratory coronavirus-2
KW - Signaling pathway
KW - Traditional Chinese medicine
UR - http://www.scopus.com/inward/record.url?scp=85089298296&partnerID=8YFLogxK
U2 - 10.1016/j.phymed.2020.153297
DO - 10.1016/j.phymed.2020.153297
M3 - Review article
C2 - 32798019
AN - SCOPUS:85089298296
SN - 0944-7113
VL - 85
JO - Phytomedicine
JF - Phytomedicine
M1 - 153297
ER -
