Therapeutic monitoring of antibiotics. New methodologies: Biosensors

Dagoberto Soto, Camila Silva, Max Andresen V., Natalia Soto, Kwok Yin Wong, Max Andresen

Research output: Journal article publicationJournal articleAcademic researchpeer-review

4 Citations (Scopus)

Abstract

The pharmacokinetics of antibiotics, especially in severely ill patients, may be profoundly altered due to multiple pathophysiological changes. Recent studies have shown that empiric dosing recommendations for ICU patients are inadequate to effectively treat a broad range of susceptible organisms and need to be reconsidered. Therapeutic drug monitoring (TDM) is an important mean for optimizing drug utilization and doses for the purpose of improving the clinical effectiveness. However, it is very challenging to quantify plasma antibiotic concentrations in clinical situations as a routine practice, because of the high costs and complexities associated with advanced instrumental techniques. Currently there are not routine and low cost methods to determine the presence and concentration of β-lactam antibiotics in plasma patients in a clinical setup. Indeed, such analytical methods are based on chromatographic techniques mainly used in research. Here we describe and comment different techniques, focusing on our preliminary experience using biosensors.
Original languageSpanish
Pages (from-to)1050-1057
Number of pages8
JournalRevista Medica de Chile
Volume143
Issue number8
DOIs
Publication statusPublished - 1 Jan 2015

Keywords

  • Anti-bacterial agents
  • Beta-Lactamase inhibitors
  • Drug monitoring
  • Fluorescein
  • Pharmacokinetics

ASJC Scopus subject areas

  • Medicine(all)

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