Therapeutic Compression Materials and Wound Dressings for Chronic Venous Insufficiency: A Comprehensive Review

Xinbo Wu, Rong Liu (Corresponding Author), Terence T Lao

    Research output: Journal article publicationReview articleAcademic researchpeer-review

    3 Citations (Scopus)


    Chronic venous insufficiency (CVI) is a common disorder worldwide. Related pathophysiological mechanisms reportedly involve venous pooling and reduced venous return, leading to heaviness, aching, itchiness, tiredness, varicosities, pigmentation, and even lower limb ulceration. Approaches adopted to manage CVI at various stages of clinical-etiology-anatomy-pathophysiology include compression therapy, pharmacological treatment, ultrasound treatment, surgery, electrical or wireless microcurrent stimulation, and pulsed electromagnetic treatment. Among these, polymer-based therapeutic compression materials and wound dressings play increasingly key roles in treating all stages of CVI because of their unique physical, mechanical, chemical, and biological functions. However, the characteristics, working mechanisms, and effectiveness of these CVI treatment materials are not comprehensively understood. The present systematic review examines the structures, properties, types, and applications of various polymer-based compression materials and wound dressings used in prophylaxis and treatment of CVI. Existing problems, limitations, and future trends of CVI treatment materials are also discussed. This review could contribute to the design and application of new functional polymer materials and dressings to enhance the efficiency of CVI treatments, thereby facilitating patients' self-care ability and long-term health improvement.
    Original languageEnglish
    Pages (from-to)892-909
    Number of pages18
    JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
    Issue number3
    Publication statusPublished - 1 Apr 2020


    • chronic venous insufficiency
    • prophylaxis
    • therapeutic compression materials and textiles
    • treatment
    • wound dressings

    ASJC Scopus subject areas

    • Biomaterials
    • Biomedical Engineering

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