Theoretical study on microwave freeze-drying of an aqueous pharmaceutical excipient with the aid of dielectric material

Wei Wang, Guohua Chen

Research output: Journal article publicationJournal articleAcademic researchpeer-review

46 Citations (Scopus)

Abstract

A mathematic model of simultaneous heat and mass transfer for the dielectric material assisted microwave freeze-drying was derived and solved numerically using the finite-deference technique with two moving boundaries. Lactose, a typical pharmaceutical excipient, was used as the representative solid material in the aqueous solution to be freeze-dried. Silicon carbide (SiC) was selected as the dielectric material. Numerical results show that the dielectric material can significantly enhance the microwave freeze-drying process. Under typical operating conditions, the drying time is 43% shorter than that of ordinary microwave freeze-drying. Temperature variations at sublimation fronts were examined in order to determine the appropriate microwave power input. Profiles of temperature, ice saturation, vapor concentration, and pressure during freeze-drying are presented, and rate-controlling mechanisms are discussed.
Original languageEnglish
Pages (from-to)2147-2168
Number of pages22
JournalDrying Technology
Volume23
Issue number9-11
DOIs
Publication statusPublished - 31 Oct 2005
Externally publishedYes

Keywords

  • Heat and mass transfer
  • Lactose
  • Model
  • Moving boundary
  • Silicon carbide

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Physical and Theoretical Chemistry

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