The use of a noninvasive and nondestructive method, microcomputed tomography, to evaluate the anti-osteoporotic activity of erxian decoction, a Chinese medicinal formula, in a rat model of menopausal osteoporosis

S. C.W. Sze, Y. Tong, Y. B. Zhang, L. L.D. Zhong, A. S.L. Lau, C. M.N. Yow, Yau Ming Lai, T. B. Ng

Research output: Chapter in book / Conference proceedingConference article published in proceeding or bookAcademic researchpeer-review

Abstract

Aim of the study: The anti-osteoporotic activity of Erxian Decoction, a Chinese medicinal formula, in a rat model of menopausal osteoporosis was evaluated by microcomputed tomography (microCT). Materials and methods: Menopause causes a decline in both endocrine function and bone mineral density in human. In this study, 20-month-old female Sprague-Dawley-rats (SD-rats) with a low serum estradiol level and bone mineral density were employed. The anti-osteoporotic activity of EXD was assessed by the determination of trabecular material bone mineral density at the L2 mid-vertebral body after treatment. Serum estrogen levels were also determined to assess the effect of EXD on the endocrine status. Results: Results revealed a significant elevation in serum estradiol level and trabecular bone mineral density at the L2 mid-vertebral body in the EXD-treated menopausal rat model. Conclusions: The results obtained from the present investigation revealed that the EXD had anti-osteoporotic activity as evidenced by an increase of serum estradiol level and bone mineral density.
Original languageEnglish
Title of host publicationProceedings of the 2009 2nd International Conference on Biomedical Engineering and Informatics, BMEI 2009
DOIs
Publication statusPublished - 1 Dec 2009
Event2009 2nd International Conference on Biomedical Engineering and Informatics, BMEI 2009 - Tianjin, China
Duration: 17 Oct 200919 Oct 2009

Conference

Conference2009 2nd International Conference on Biomedical Engineering and Informatics, BMEI 2009
Country/TerritoryChina
CityTianjin
Period17/10/0919/10/09

Keywords

  • Chinese medicine
  • Erxian decoction
  • Estradiol and menopause
  • Microcomputed tomography
  • Osteoporosis

ASJC Scopus subject areas

  • Biomedical Engineering
  • Health Informatics
  • Health Information Management

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