The toxicity evaluation of nano-trititanate with bactericidal properties in vitro

R. Pan, Y. Liu, Wei Chen, G. Dawson, X. Wang, Y. Li, B. Dong, Y. Zhu

Research output: Journal article publicationJournal articleAcademic researchpeer-review

6 Citations (Scopus)


Three forms of nano-trititanate (H 2 Ti 3 O 7 nanomaterial) were prepared by a hydrothermal method to replace nano-TiO 2 for sterilizing the environment. The bactericidal capabilities of these nano-trititanates were observed to be more significant compared to nano-TiO 2 both with and without exposure to UV light. For the future commercial applications of those nano-trititanates, we investigated their cytotoxicity and genotoxicity to HEp-2 cells. As data in our study shows, nanoplate, one of the nano-trititanates, possesses the lowest toxicity to HEp-2 cells. The results indicated that the shape and length of the material only affect the toxicity of nano-trititanate but not its bactericidal effect. Thus, through manipulating the shape or length of nano-trititanate, we may obtain a more powerful bactericidal reagent with lower toxicity to the human body.
Original languageEnglish
Pages (from-to)327-337
Number of pages11
Issue number3
Publication statusPublished - 1 May 2012
Externally publishedYes


  • E. coli
  • HEp-2 cells
  • Nano-trititanate
  • Nanotoxicology
  • Particle toxicology

ASJC Scopus subject areas

  • Biomedical Engineering
  • Toxicology

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