The study of 9,10-dihydroacridine derivatives as a new and effective molecular scaffold for antibacterial agent development

Cui Cui Chen; Yi Qi Zhang; Dong Xiao Zhong; Xuan He Huang; Yi Han Zhang; Wen Hao Jiang; Ming Li; Qian Chen; Wing Leung Wong; Yu Jing Lu

doi:10.1016/j.bbrc.2021.01.096

The study of 9,10-dihydroacridine derivatives as a new and effective molecular scaffold for antibacterial agent development

Cui Cui Chen, Yi Qi Zhang, Dong Xiao Zhong, Xuan He Huang, Yi Han Zhang, Wen Hao Jiang, Ming Li, Qian Chen, Wing Leung Wong, Yu Jing Lu

Research output: Journal article publication › Journal article › Academic research › peer-review

4 Citations (Scopus)

Abstract

The emergence of worldwide spreading drug-resistant bacteria has been a serious threat to public health during the past decades. The development of new and effective antibacterial agents to address this critical issue is an urgent action. In the present study, we investigated the antibacterial activity of two 9,10-dihydroacridine derivatives and their mechanism. Both compounds were found possessing strong antibacterial activity against some selected Gram-positive bacteria including MRSA, VISA and VRE. The biological study suggests that the compounds promoted FtsZ polymerization and also disrupted Z-ring formation at the dividing site and consequently, the bacterial cell division is interrupted and causing cell death.

Original language	English
Pages (from-to)	40-45
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	546
DOIs	https://doi.org/10.1016/j.bbrc.2021.01.096
Publication status	Published - 26 Mar 2021
Externally published	Yes

Keywords

9,10-Dihydroacridine derivative
Antibacterial activity
Drug-resistant strain
FtsZ inhibitor

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

More information

10.1016/j.bbrc.2021.01.096

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title = "The study of 9,10-dihydroacridine derivatives as a new and effective molecular scaffold for antibacterial agent development",

abstract = "The emergence of worldwide spreading drug-resistant bacteria has been a serious threat to public health during the past decades. The development of new and effective antibacterial agents to address this critical issue is an urgent action. In the present study, we investigated the antibacterial activity of two 9,10-dihydroacridine derivatives and their mechanism. Both compounds were found possessing strong antibacterial activity against some selected Gram-positive bacteria including MRSA, VISA and VRE. The biological study suggests that the compounds promoted FtsZ polymerization and also disrupted Z-ring formation at the dividing site and consequently, the bacterial cell division is interrupted and causing cell death.",

keywords = "9,10-Dihydroacridine derivative, Antibacterial activity, Drug-resistant strain, FtsZ inhibitor",

author = "Chen, {Cui Cui} and Zhang, {Yi Qi} and Zhong, {Dong Xiao} and Huang, {Xuan He} and Zhang, {Yi Han} and Jiang, {Wen Hao} and Ming Li and Qian Chen and Wong, {Wing Leung} and Lu, {Yu Jing}",

note = "Funding Information: This study was supported by the National Natural Science Foundation of China ( 81700076 and 81473082 ), Nature Science Foundation of Guangdong Province , China (Grant No.: 2017A030313078 ; 2017A030313071 ; 2019A1515011799 ), the Department of Agriculture and Rural Affairs of Guangdong Province , China ( 2018LM2175 ), the Science and Technology Planning Project of Guangdong Province (No. 2017A010103044 ), and Jiangmen Program for Innovative Research Team (No. 2018630100180019806). Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",

year = "2021",

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day = "26",

doi = "10.1016/j.bbrc.2021.01.096",

language = "English",

volume = "546",

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The study of 9,10-dihydroacridine derivatives as a new and effective molecular scaffold for antibacterial agent development. / Chen, Cui Cui; Zhang, Yi Qi; Zhong, Dong Xiao et al.
In: Biochemical and Biophysical Research Communications, Vol. 546, 26.03.2021, p. 40-45.

Research output: Journal article publication › Journal article › Academic research › peer-review

TY - JOUR

T1 - The study of 9,10-dihydroacridine derivatives as a new and effective molecular scaffold for antibacterial agent development

AU - Chen, Cui Cui

AU - Zhang, Yi Qi

AU - Zhong, Dong Xiao

AU - Huang, Xuan He

AU - Zhang, Yi Han

AU - Jiang, Wen Hao

AU - Li, Ming

AU - Chen, Qian

AU - Wong, Wing Leung

AU - Lu, Yu Jing

N1 - Funding Information: This study was supported by the National Natural Science Foundation of China ( 81700076 and 81473082 ), Nature Science Foundation of Guangdong Province , China (Grant No.: 2017A030313078 ; 2017A030313071 ; 2019A1515011799 ), the Department of Agriculture and Rural Affairs of Guangdong Province , China ( 2018LM2175 ), the Science and Technology Planning Project of Guangdong Province (No. 2017A010103044 ), and Jiangmen Program for Innovative Research Team (No. 2018630100180019806). Publisher Copyright: © 2021 Elsevier Inc.

PY - 2021/3/26

Y1 - 2021/3/26

N2 - The emergence of worldwide spreading drug-resistant bacteria has been a serious threat to public health during the past decades. The development of new and effective antibacterial agents to address this critical issue is an urgent action. In the present study, we investigated the antibacterial activity of two 9,10-dihydroacridine derivatives and their mechanism. Both compounds were found possessing strong antibacterial activity against some selected Gram-positive bacteria including MRSA, VISA and VRE. The biological study suggests that the compounds promoted FtsZ polymerization and also disrupted Z-ring formation at the dividing site and consequently, the bacterial cell division is interrupted and causing cell death.

AB - The emergence of worldwide spreading drug-resistant bacteria has been a serious threat to public health during the past decades. The development of new and effective antibacterial agents to address this critical issue is an urgent action. In the present study, we investigated the antibacterial activity of two 9,10-dihydroacridine derivatives and their mechanism. Both compounds were found possessing strong antibacterial activity against some selected Gram-positive bacteria including MRSA, VISA and VRE. The biological study suggests that the compounds promoted FtsZ polymerization and also disrupted Z-ring formation at the dividing site and consequently, the bacterial cell division is interrupted and causing cell death.

KW - 9,10-Dihydroacridine derivative

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KW - Drug-resistant strain

KW - FtsZ inhibitor

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AN - SCOPUS:85100647033

SN - 0006-291X

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SP - 40

EP - 45

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

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The study of 9,10-dihydroacridine derivatives as a new and effective molecular scaffold for antibacterial agent development

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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