@article{75f3c5477afb403ba92191cb37db164b,
title = "The Small Open Reading Frame-Encoded Peptides: Advances in Methodologies and Functional Studies",
abstract = "Small open reading frames (sORFs) are an important class of genes with less than 100 codons. They were historically annotated as noncoding or even junk sequences. In recent years, accumulating evidence suggests that sORFs could encode a considerable number of polypeptides, many of which play important roles in both physiology and disease pathology. However, it has been technically challenging to directly detect sORF-encoded peptides (SEPs). Here, we discuss the latest advances in methodologies for identifying SEPs with mass spectrometry, as well as the progress on functional studies of SEPs.",
keywords = "mass spectrometry, proteins, proteomics, small open reading frames, sORF-encoded peptides",
author = "Lei Chen and Ying Yang and Yuanliang Zhang and Kecheng Li and Hongmin Cai and Hongwei Wang and Qian Zhao",
note = "Funding Information: Our work on sORFs is funded by Research Grants Council (RGC) ECS 25301518, GRF 15305821 and RGC-CRF Equipment C5033-19E. We also acknowledge the funding support from Laboratory for Synthetic Chemistry and Chemical Biology under the Health@InnoHK Program launched by Innovation and Technology Commission, The Government of Hong Kong Special Administrative Region of the People's Republic of China. Funding Information: Our work on sORFs is funded by Research Grants Council (RGC) ECS 25301518, GRF 15305821 and RGC‐CRF Equipment C5033‐19E. We also acknowledge the funding support from Laboratory for Synthetic Chemistry and Chemical Biology under the Health@InnoHK Program launched by Innovation and Technology Commission, The Government of Hong Kong Special Administrative Region of the People's Republic of China. Publisher Copyright: {\textcopyright} 2021 Wiley-VCH GmbH.",
year = "2022",
month = apr,
day = "20",
doi = "10.1002/cbic.202100534",
language = "English",
volume = "23",
journal = "ChemBioChem",
issn = "1439-4227",
publisher = "John Wiley and Sons Inc.",
number = "8",
}