The significance of PTEN/AKT pathway in glioma and its relation to proliferation,adhesion and apoptosis of glioma cells

C. S K Luk; Shing Shun Tony To

The significance of PTEN/AKT pathway in glioma and its relation to proliferation,adhesion and apoptosis of glioma cells

C. S K Luk, Shing Shun Tony To

Research output: Chapter in book / Conference proceeding › Chapter in an edited book (as author) › Academic research › peer-review

Abstract

Glioblastomas multiforme (GBM) is a highly invasive and aggressive primary braintumor in adults, which occurs most frequently through loss of phosphatase and tensinhomolog deleted on chromosome 10 (PTEN) function. The tumor-suppressive propertiesof PTEN inhibit the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway throughdephosphorylation of phosphatidylinositol 3,4,5-triphosphate (PtdIns(3,4,5)P3).PTEN/PI3K/Akt constitutes an important signaling pathway regulating various cellularresponses including cell proliferation, cell growth, metabolism, apoptosis and migration.Loss of PTEN function causes accumulation of PtdIns(3,4,5)P3 mimicking the effect ofPI3K activation and triggering the activation of its downstream effectors. Thisunbalanced reaction leads to deregulation of PI3K/Akt signaling pathway, which isconsidered an essential driver in gliomagenesis.

Original language	English
Title of host publication	Gliomas
Subtitle of host publication	Symptoms, Diagnosis and Treatment Options
Publisher	Nova Science Publishers, Inc.
Pages	307-320
Number of pages	14
ISBN (Print)	9781626180895
Publication status	Published - 1 May 2013

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Medicine(all)

Cite this

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abstract = "Glioblastomas multiforme (GBM) is a highly invasive and aggressive primary braintumor in adults, which occurs most frequently through loss of phosphatase and tensinhomolog deleted on chromosome 10 (PTEN) function. The tumor-suppressive propertiesof PTEN inhibit the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway throughdephosphorylation of phosphatidylinositol 3,4,5-triphosphate (PtdIns(3,4,5)P3).PTEN/PI3K/Akt constitutes an important signaling pathway regulating various cellularresponses including cell proliferation, cell growth, metabolism, apoptosis and migration.Loss of PTEN function causes accumulation of PtdIns(3,4,5)P3 mimicking the effect ofPI3K activation and triggering the activation of its downstream effectors. Thisunbalanced reaction leads to deregulation of PI3K/Akt signaling pathway, which isconsidered an essential driver in gliomagenesis.",

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The significance of PTEN/AKT pathway in glioma and its relation to proliferation,adhesion and apoptosis of glioma cells. / Luk, C. S K; To, Shing Shun Tony.

Gliomas: Symptoms, Diagnosis and Treatment Options. Nova Science Publishers, Inc., 2013. p. 307-320.

Research output: Chapter in book / Conference proceeding › Chapter in an edited book (as author) › Academic research › peer-review

TY - CHAP

T1 - The significance of PTEN/AKT pathway in glioma and its relation to proliferation,adhesion and apoptosis of glioma cells

AU - Luk, C. S K

AU - To, Shing Shun Tony

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N2 - Glioblastomas multiforme (GBM) is a highly invasive and aggressive primary braintumor in adults, which occurs most frequently through loss of phosphatase and tensinhomolog deleted on chromosome 10 (PTEN) function. The tumor-suppressive propertiesof PTEN inhibit the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway throughdephosphorylation of phosphatidylinositol 3,4,5-triphosphate (PtdIns(3,4,5)P3).PTEN/PI3K/Akt constitutes an important signaling pathway regulating various cellularresponses including cell proliferation, cell growth, metabolism, apoptosis and migration.Loss of PTEN function causes accumulation of PtdIns(3,4,5)P3 mimicking the effect ofPI3K activation and triggering the activation of its downstream effectors. Thisunbalanced reaction leads to deregulation of PI3K/Akt signaling pathway, which isconsidered an essential driver in gliomagenesis.

AB - Glioblastomas multiforme (GBM) is a highly invasive and aggressive primary braintumor in adults, which occurs most frequently through loss of phosphatase and tensinhomolog deleted on chromosome 10 (PTEN) function. The tumor-suppressive propertiesof PTEN inhibit the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway throughdephosphorylation of phosphatidylinositol 3,4,5-triphosphate (PtdIns(3,4,5)P3).PTEN/PI3K/Akt constitutes an important signaling pathway regulating various cellularresponses including cell proliferation, cell growth, metabolism, apoptosis and migration.Loss of PTEN function causes accumulation of PtdIns(3,4,5)P3 mimicking the effect ofPI3K activation and triggering the activation of its downstream effectors. Thisunbalanced reaction leads to deregulation of PI3K/Akt signaling pathway, which isconsidered an essential driver in gliomagenesis.

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M3 - Chapter in an edited book (as author)

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PB - Nova Science Publishers, Inc.

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The significance of PTEN/AKT pathway in glioma and its relation to proliferation,adhesion and apoptosis of glioma cells

Abstract

ASJC Scopus subject areas

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