The significance of PTEN/AKT pathway in glioma and its relation to proliferation,adhesion and apoptosis of glioma cells

C. S K Luk, Shing Shun Tony To

Research output: Chapter in book / Conference proceedingChapter in an edited book (as author)Academic researchpeer-review

Abstract

Glioblastomas multiforme (GBM) is a highly invasive and aggressive primary braintumor in adults, which occurs most frequently through loss of phosphatase and tensinhomolog deleted on chromosome 10 (PTEN) function. The tumor-suppressive propertiesof PTEN inhibit the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway throughdephosphorylation of phosphatidylinositol 3,4,5-triphosphate (PtdIns(3,4,5)P3).PTEN/PI3K/Akt constitutes an important signaling pathway regulating various cellularresponses including cell proliferation, cell growth, metabolism, apoptosis and migration.Loss of PTEN function causes accumulation of PtdIns(3,4,5)P3 mimicking the effect ofPI3K activation and triggering the activation of its downstream effectors. Thisunbalanced reaction leads to deregulation of PI3K/Akt signaling pathway, which isconsidered an essential driver in gliomagenesis.
Original languageEnglish
Title of host publicationGliomas
Subtitle of host publicationSymptoms, Diagnosis and Treatment Options
PublisherNova Science Publishers, Inc.
Pages307-320
Number of pages14
ISBN (Print)9781626180895
Publication statusPublished - 1 May 2013

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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