Glioblastomas multiforme (GBM) is a highly invasive and aggressive primary braintumor in adults, which occurs most frequently through loss of phosphatase and tensinhomolog deleted on chromosome 10 (PTEN) function. The tumor-suppressive propertiesof PTEN inhibit the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway throughdephosphorylation of phosphatidylinositol 3,4,5-triphosphate (PtdIns(3,4,5)P3).PTEN/PI3K/Akt constitutes an important signaling pathway regulating various cellularresponses including cell proliferation, cell growth, metabolism, apoptosis and migration.Loss of PTEN function causes accumulation of PtdIns(3,4,5)P3 mimicking the effect ofPI3K activation and triggering the activation of its downstream effectors. Thisunbalanced reaction leads to deregulation of PI3K/Akt signaling pathway, which isconsidered an essential driver in gliomagenesis.
|Title of host publication||Gliomas|
|Subtitle of host publication||Symptoms, Diagnosis and Treatment Options|
|Publisher||Nova Science Publishers, Inc.|
|Number of pages||14|
|Publication status||Published - 1 May 2013|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)