The role of sleep deprivation and circadian rhythm disruption as risk factors of Alzheimer's disease

Hao Wu; Sophie Dunnett; Yuen Shan Ho; Raymond Chuen Chung Chang

doi:10.1016/j.yfrne.2019.100764

The role of sleep deprivation and circadian rhythm disruption as risk factors of Alzheimer's disease

Hao Wu, Sophie Dunnett, Yuen Shan Ho, Raymond Chuen Chung Chang

Research output: Journal article publication › Review article › Academic research › peer-review

90 Citations (Scopus)

Abstract

Emerging evidence suggests that sleep deprivation (SD) and circadian rhythm disruption (CRD) may interact and increase the risk for the development of Alzheimer's disease (AD). This review inspects different pathophysiological aspects of SD and CRD, and shows that the two may impair the glymphatic-vascular-lymphatic clearance of brain macromolecules (e.g., β-amyloid and microtubule associated protein tau), increase local brain oxidative stress and diminish circulatory melatonin levels. Lastly, this review looks into the potential association between sleep and circadian rhythm with stress granule formation, which might be a new mechanism along the AD pathogenic pathway. In summary, SD and CRD is likely to be associated with a positive risk in developing Alzheimer's disease in humans.

Original language	English
Article number	100764
Journal	Frontiers in Neuroendocrinology
Volume	54
DOIs	https://doi.org/10.1016/j.yfrne.2019.100764
Publication status	Published - Jul 2019

Keywords

Alzheimer's disease
Circadian rhythm
Dural lymphatics
Glymphatic
Melatonin
Orexin
Oxidative stress
Sleep
Stress granules

ASJC Scopus subject areas

Endocrine and Autonomic Systems

More information

10.1016/j.yfrne.2019.100764

Cite this

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title = "The role of sleep deprivation and circadian rhythm disruption as risk factors of Alzheimer's disease",

abstract = "Emerging evidence suggests that sleep deprivation (SD) and circadian rhythm disruption (CRD) may interact and increase the risk for the development of Alzheimer's disease (AD). This review inspects different pathophysiological aspects of SD and CRD, and shows that the two may impair the glymphatic-vascular-lymphatic clearance of brain macromolecules (e.g., β-amyloid and microtubule associated protein tau), increase local brain oxidative stress and diminish circulatory melatonin levels. Lastly, this review looks into the potential association between sleep and circadian rhythm with stress granule formation, which might be a new mechanism along the AD pathogenic pathway. In summary, SD and CRD is likely to be associated with a positive risk in developing Alzheimer's disease in humans.",

keywords = "Alzheimer's disease, Circadian rhythm, Dural lymphatics, Glymphatic, Melatonin, Orexin, Oxidative stress, Sleep, Stress granules",

author = "Hao Wu and Sophie Dunnett and Ho, {Yuen Shan} and Chang, {Raymond Chuen Chung}",

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AU - Wu, Hao

AU - Dunnett, Sophie

AU - Ho, Yuen Shan

AU - Chang, Raymond Chuen Chung

PY - 2019/7

Y1 - 2019/7

N2 - Emerging evidence suggests that sleep deprivation (SD) and circadian rhythm disruption (CRD) may interact and increase the risk for the development of Alzheimer's disease (AD). This review inspects different pathophysiological aspects of SD and CRD, and shows that the two may impair the glymphatic-vascular-lymphatic clearance of brain macromolecules (e.g., β-amyloid and microtubule associated protein tau), increase local brain oxidative stress and diminish circulatory melatonin levels. Lastly, this review looks into the potential association between sleep and circadian rhythm with stress granule formation, which might be a new mechanism along the AD pathogenic pathway. In summary, SD and CRD is likely to be associated with a positive risk in developing Alzheimer's disease in humans.

AB - Emerging evidence suggests that sleep deprivation (SD) and circadian rhythm disruption (CRD) may interact and increase the risk for the development of Alzheimer's disease (AD). This review inspects different pathophysiological aspects of SD and CRD, and shows that the two may impair the glymphatic-vascular-lymphatic clearance of brain macromolecules (e.g., β-amyloid and microtubule associated protein tau), increase local brain oxidative stress and diminish circulatory melatonin levels. Lastly, this review looks into the potential association between sleep and circadian rhythm with stress granule formation, which might be a new mechanism along the AD pathogenic pathway. In summary, SD and CRD is likely to be associated with a positive risk in developing Alzheimer's disease in humans.

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KW - Circadian rhythm

KW - Dural lymphatics

KW - Glymphatic

KW - Melatonin

KW - Orexin

KW - Oxidative stress

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The role of sleep deprivation and circadian rhythm disruption as risk factors of Alzheimer's disease

Abstract

Keywords

ASJC Scopus subject areas

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