The role of Myc and let-7a in glioblastoma, glucose metabolism and response to therapy

Gang Wang, Jun Jie Wang, Hua Fu Zhao, Jing Wang, Shing Shun Tony To

Research output: Journal article publicationReview articleAcademic researchpeer-review

22 Citations (Scopus)

Abstract

Glioblastoma multiforme (GBM) is thought to result from an imbalance between glucose metabolism and tumor growth. The Myc oncogene and lethal-7a microRNA (let-7a miRNA) have been suggested to cooperatively regulate multiple downstream targets leading to changes in chromosome stability, gene mutations, and/or modulation of tumor growth. Here, we review the roles of Myc and let-7a in glucose metabolism and tumor growth and addresses their future potential as prognostic markers and therapeutic tools in GBM. We focus on the functions of Myc and let-7a in glucose uptake, tumor survival, proliferation, and mobility of glioma cells. In addition, we discuss how regulation of different pathways by Myc or let-7a may be useful for future GBM therapies. A large body of evidence suggests that targeting Myc and let-7a may provide a selective mechanism for the deregulation of glucose metabolic pathways in glioma cells. Indeed, Myc and let-7a are aberrantly expressed in GBM and have been linked to the regulation of cell growth and glucose metabolism in GBM. This article is part of a Special Issue entitled "Targeting alternative glucose metabolism and regulate pathways in GBM cells for future glioblastoma therapies".
Original languageEnglish
Pages (from-to)84-92
Number of pages9
JournalArchives of Biochemistry and Biophysics
Volume580
DOIs
Publication statusPublished - 13 Jul 2015

Keywords

  • Glioblastoma
  • Glucose metabolism
  • Let-7a miRNA
  • Myc
  • Pathways
  • Tumor growth

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology

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