TY - JOUR
T1 - The role of muscle mass and body fat on disability among older adults
T2 - A cross-national analysis
AU - Tyrovolas, Stefanos
AU - Koyanagi, Ai
AU - Olaya, Beatriz
AU - Ayuso-Mateos, Jose Luis
AU - Miret, Marta
AU - Chatterji, Somnath
AU - Tobiasz-Adamczyk, Beata
AU - Koskinen, Seppo
AU - Leonardi, Matilde
AU - Haro, Josep Maria
N1 - Funding Information:
SAGE is supported by the United States National Institute on Aging's Division of Behavioral and Social Research through Interagency Agreements (OGHA 04034785 ; YA1323-08-CN-0020 ; Y1-AG-1005-01 ) and through research grants ( R01-AG034479 and R21-AG034263 ) and the WHO's Department of Health Statistics and Information Systems . The research leading to these results has received funding from the European Community's Seventh Framework Programme ( FP7/2007-2013 ) under grant agreement number 223071 (COURAGE in Europe), from the Instituto de Salud Carlos III-FIS research grants number PS09/00295 and PS09/01845 , and from the Spanish Ministry of Science and Innovation ACI-Promociona ( ACI2009-1010 ). The study was also supported by the Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III . The views expressed in this paper are those of the author(s) and do not necessarily represent the views or policies of the WHO. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Funding Information:
Stefanos Tyrovolas received a scholarship from the Foundation for Education and European Culture (IPEP) to undertake his post-doctoral research, of which this work is a part. Ai Koyanagi's work was supported by the Miguel Servet contract financed by the CP13/00150 project, integrated into the National R + D + I and funded by the ISCIII – General Branch Evaluation and Promotion of Health Research – and the European Regional Development Fund (ERDF). Beatriz Olaya's work was supported by the Sara Borrell postdoctoral program (reference no. CD12/00429) from the Instituto de Salud Carlos III (Spain).
Publisher Copyright:
© 2015 Elsevier Inc.
PY - 2015/9/1
Y1 - 2015/9/1
N2 - Background: The aim of this study was to evaluate the association of sarcopenia and sarcopenic obesity with disability among older adults (≥. 65. years old) in nine high-, middle- and low-income countries from Asia, Africa, Europe, and Latin America. Methods: Data were available for 53,289 people aged ≥. 18. years who participated in the Collaborative Research on Ageing in Europe (COURAGE) survey conducted in Finland, Poland, and Spain, and the WHO Study on global AGEing and adult health (SAGE) survey conducted in China, Ghana, India, Mexico, Russia, and South Africa, between 2007 and 2012. Skeletal muscle mass, skeletal muscle mass index, and percent body fat were calculated with specific population formulas. Sarcopenia and sarcopenic obesity were defined by specific cut-offs used in previous studies. Disability was assessed with the WHODAS 2.0 score (range 0-100) with higher scores corresponding to higher levels of disability. Multivariable linear regression analysis was conducted with disability as the outcome. Results: The analytical sample consisted of 18,363 people (males; n. =. 8116, females; n. =. 10247) aged ≥. 65. years with mean (SD) age 72.9 (11.1) years. In the fully-adjusted overall analysis, sarcopenic obesity was associated with greater levels of disability [b-coefficient 3.01 (95% CI 1.14-4.88)]. In terms of country-wise analyses, sarcopenia was associated with higher WHODAS 2.0 scores in China [b-coefficient 4.56 (95% CI: 3.25-5.87)], Poland [b-coefficient 6.66 (95% CI: 2.17-11.14)], Russia [b-coefficient 5.60 (95% CI: 2.03-9.16)], and South Africa [b-coefficient 7.75 (95% CI: 1.56-13.94)]. Conclusions: Prevention of muscle mass decline may contribute to reducing the global burden of disability.
AB - Background: The aim of this study was to evaluate the association of sarcopenia and sarcopenic obesity with disability among older adults (≥. 65. years old) in nine high-, middle- and low-income countries from Asia, Africa, Europe, and Latin America. Methods: Data were available for 53,289 people aged ≥. 18. years who participated in the Collaborative Research on Ageing in Europe (COURAGE) survey conducted in Finland, Poland, and Spain, and the WHO Study on global AGEing and adult health (SAGE) survey conducted in China, Ghana, India, Mexico, Russia, and South Africa, between 2007 and 2012. Skeletal muscle mass, skeletal muscle mass index, and percent body fat were calculated with specific population formulas. Sarcopenia and sarcopenic obesity were defined by specific cut-offs used in previous studies. Disability was assessed with the WHODAS 2.0 score (range 0-100) with higher scores corresponding to higher levels of disability. Multivariable linear regression analysis was conducted with disability as the outcome. Results: The analytical sample consisted of 18,363 people (males; n. =. 8116, females; n. =. 10247) aged ≥. 65. years with mean (SD) age 72.9 (11.1) years. In the fully-adjusted overall analysis, sarcopenic obesity was associated with greater levels of disability [b-coefficient 3.01 (95% CI 1.14-4.88)]. In terms of country-wise analyses, sarcopenia was associated with higher WHODAS 2.0 scores in China [b-coefficient 4.56 (95% CI: 3.25-5.87)], Poland [b-coefficient 6.66 (95% CI: 2.17-11.14)], Russia [b-coefficient 5.60 (95% CI: 2.03-9.16)], and South Africa [b-coefficient 7.75 (95% CI: 1.56-13.94)]. Conclusions: Prevention of muscle mass decline may contribute to reducing the global burden of disability.
KW - Disability
KW - Older adults
KW - Sarcopenia
KW - Sarcopenic obesity
KW - WHODAS 2.0
UR - http://www.scopus.com/inward/record.url?scp=84934901936&partnerID=8YFLogxK
U2 - 10.1016/j.exger.2015.06.002
DO - 10.1016/j.exger.2015.06.002
M3 - Journal article
C2 - 26048566
AN - SCOPUS:84934901936
SN - 0531-5565
VL - 69
SP - 27
EP - 35
JO - Experimental Gerontology
JF - Experimental Gerontology
ER -