Abstract
Latent inhibition (LI) consists in a retardation of conditioning seen when to-be-conditioned stimulus is first presented a number of times without other consequence. Disruption of LI has been proposed as a possible model of the cognitive abnormality that underlies the positive psychotic symptoms of acute schizophrenia. We review here evidence in support of the model, including experiments tending to show that: (1) disruption of LI is characteristic of acute, positively-symptomatic schizophrenia; (2) LI depends upon dopaminergic activity; (3) LI depends specifically upon dopamine release in n. accumbens; (4) LI depends upon the integrity of the hippocampal formation and the retrohippocampal region reciprocally connected to the hippocampal formation; (5) the roles of n. accumbens and the hippocampal system in LI are interconnected.
Original language | English |
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Journal | Behavioural Brain Research |
Volume | 71 |
Issue number | 1-2 |
DOIs | |
Publication status | Published - 1 Jan 1995 |
Externally published | Yes |
Keywords
- Hippocampal formation
- Latent inhibition
- Mesolimbic dopamine system
- Nucleus accumbens
- Schizophrenia
ASJC Scopus subject areas
- Behavioral Neuroscience