The role of mesolimbic dopaminergic and retrohippocampal afferents to the nucleus accumbens in latent inhibition: implications for schizophrenia

Jeffrey A. Gray; Michael H. Joseph; David R. Hemsley; Andrew M.J. Young; E. Clea Warburton; Pascale Boulenguez; Gregory A. Grigoryan; Scott L. Peters; J. N.P. Rawlins; C. T. Taib; Kay Yan Benjamin Yee; Helen Cassaday; Ina Weiner; Gilad Gal; Oleg Gusak; Daphna Joel; Eran Shadach; Uri Shalev; Ricardo Tarrasch; Joram Feldon

doi:10.1016/0166-4328(95)00154-9

The role of mesolimbic dopaminergic and retrohippocampal afferents to the nucleus accumbens in latent inhibition: implications for schizophrenia

Jeffrey A. Gray, Michael H. Joseph, David R. Hemsley, Andrew M.J. Young, E. Clea Warburton, Pascale Boulenguez, Gregory A. Grigoryan, Scott L. Peters, J. N.P. Rawlins, C. T. Taib, Kay Yan Benjamin Yee, Helen Cassaday, Ina Weiner, Gilad Gal, Oleg Gusak, Daphna Joel, Eran Shadach, Uri Shalev, Ricardo Tarrasch, Joram Feldon

Research output: Journal article publication › Journal article › Academic research › peer-review

150 Citations (Scopus)

Abstract

Latent inhibition (LI) consists in a retardation of conditioning seen when to-be-conditioned stimulus is first presented a number of times without other consequence. Disruption of LI has been proposed as a possible model of the cognitive abnormality that underlies the positive psychotic symptoms of acute schizophrenia. We review here evidence in support of the model, including experiments tending to show that: (1) disruption of LI is characteristic of acute, positively-symptomatic schizophrenia; (2) LI depends upon dopaminergic activity; (3) LI depends specifically upon dopamine release in n. accumbens; (4) LI depends upon the integrity of the hippocampal formation and the retrohippocampal region reciprocally connected to the hippocampal formation; (5) the roles of n. accumbens and the hippocampal system in LI are interconnected.

Original language	English
Journal	Behavioural Brain Research
Volume	71
Issue number	1-2
DOIs	https://doi.org/10.1016/0166-4328(95)00154-9
Publication status	Published - 1 Jan 1995
Externally published	Yes

Keywords

Hippocampal formation
Latent inhibition
Mesolimbic dopamine system
Nucleus accumbens
Schizophrenia

ASJC Scopus subject areas

Behavioral Neuroscience

More information

10.1016/0166-4328(95)00154-9

Cite this

Gray, J. A., Joseph, M. H., Hemsley, D. R., Young, A. M. J., Clea Warburton, E., Boulenguez, P., Grigoryan, G. A., Peters, S. L., Rawlins, J. N. P., Taib, C. T., Yee, K. Y. B., Cassaday, H., Weiner, I., Gal, G., Gusak, O., Joel, D., Shadach, E., Shalev, U., Tarrasch, R., & Feldon, J. (1995). The role of mesolimbic dopaminergic and retrohippocampal afferents to the nucleus accumbens in latent inhibition: implications for schizophrenia. Behavioural Brain Research, 71(1-2). https://doi.org/10.1016/0166-4328(95)00154-9

Gray, Jeffrey A. ; Joseph, Michael H. ; Hemsley, David R. ; Young, Andrew M.J. ; Clea Warburton, E. ; Boulenguez, Pascale ; Grigoryan, Gregory A. ; Peters, Scott L. ; Rawlins, J. N.P. ; Taib, C. T. ; Yee, Kay Yan Benjamin ; Cassaday, Helen ; Weiner, Ina ; Gal, Gilad ; Gusak, Oleg ; Joel, Daphna ; Shadach, Eran ; Shalev, Uri ; Tarrasch, Ricardo ; Feldon, Joram. / The role of mesolimbic dopaminergic and retrohippocampal afferents to the nucleus accumbens in latent inhibition: implications for schizophrenia. In: Behavioural Brain Research. 1995 ; Vol. 71, No. 1-2.

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title = "The role of mesolimbic dopaminergic and retrohippocampal afferents to the nucleus accumbens in latent inhibition: implications for schizophrenia",

abstract = "Latent inhibition (LI) consists in a retardation of conditioning seen when to-be-conditioned stimulus is first presented a number of times without other consequence. Disruption of LI has been proposed as a possible model of the cognitive abnormality that underlies the positive psychotic symptoms of acute schizophrenia. We review here evidence in support of the model, including experiments tending to show that: (1) disruption of LI is characteristic of acute, positively-symptomatic schizophrenia; (2) LI depends upon dopaminergic activity; (3) LI depends specifically upon dopamine release in n. accumbens; (4) LI depends upon the integrity of the hippocampal formation and the retrohippocampal region reciprocally connected to the hippocampal formation; (5) the roles of n. accumbens and the hippocampal system in LI are interconnected.",

keywords = "Hippocampal formation, Latent inhibition, Mesolimbic dopamine system, Nucleus accumbens, Schizophrenia",

author = "Gray, {Jeffrey A.} and Joseph, {Michael H.} and Hemsley, {David R.} and Young, {Andrew M.J.} and {Clea Warburton}, E. and Pascale Boulenguez and Grigoryan, {Gregory A.} and Peters, {Scott L.} and Rawlins, {J. N.P.} and Taib, {C. T.} and Yee, {Kay Yan Benjamin} and Helen Cassaday and Ina Weiner and Gilad Gal and Oleg Gusak and Daphna Joel and Eran Shadach and Uri Shalev and Ricardo Tarrasch and Joram Feldon",

year = "1995",

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doi = "10.1016/0166-4328(95)00154-9",

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Gray, JA, Joseph, MH, Hemsley, DR, Young, AMJ, Clea Warburton, E, Boulenguez, P, Grigoryan, GA, Peters, SL, Rawlins, JNP, Taib, CT, Yee, KYB, Cassaday, H, Weiner, I, Gal, G, Gusak, O, Joel, D, Shadach, E, Shalev, U, Tarrasch, R & Feldon, J 1995, 'The role of mesolimbic dopaminergic and retrohippocampal afferents to the nucleus accumbens in latent inhibition: implications for schizophrenia', Behavioural Brain Research, vol. 71, no. 1-2. https://doi.org/10.1016/0166-4328(95)00154-9

The role of mesolimbic dopaminergic and retrohippocampal afferents to the nucleus accumbens in latent inhibition: implications for schizophrenia. / Gray, Jeffrey A.; Joseph, Michael H.; Hemsley, David R.; Young, Andrew M.J.; Clea Warburton, E.; Boulenguez, Pascale; Grigoryan, Gregory A.; Peters, Scott L.; Rawlins, J. N.P.; Taib, C. T.; Yee, Kay Yan Benjamin; Cassaday, Helen; Weiner, Ina; Gal, Gilad; Gusak, Oleg; Joel, Daphna; Shadach, Eran; Shalev, Uri; Tarrasch, Ricardo; Feldon, Joram.

In: Behavioural Brain Research, Vol. 71, No. 1-2, 01.01.1995.

Research output: Journal article publication › Journal article › Academic research › peer-review

TY - JOUR

T1 - The role of mesolimbic dopaminergic and retrohippocampal afferents to the nucleus accumbens in latent inhibition: implications for schizophrenia

AU - Gray, Jeffrey A.

AU - Joseph, Michael H.

AU - Hemsley, David R.

AU - Young, Andrew M.J.

AU - Clea Warburton, E.

AU - Boulenguez, Pascale

AU - Grigoryan, Gregory A.

AU - Peters, Scott L.

AU - Rawlins, J. N.P.

AU - Taib, C. T.

AU - Yee, Kay Yan Benjamin

AU - Cassaday, Helen

AU - Weiner, Ina

AU - Gal, Gilad

AU - Gusak, Oleg

AU - Joel, Daphna

AU - Shadach, Eran

AU - Shalev, Uri

AU - Tarrasch, Ricardo

AU - Feldon, Joram

PY - 1995/1/1

Y1 - 1995/1/1

N2 - Latent inhibition (LI) consists in a retardation of conditioning seen when to-be-conditioned stimulus is first presented a number of times without other consequence. Disruption of LI has been proposed as a possible model of the cognitive abnormality that underlies the positive psychotic symptoms of acute schizophrenia. We review here evidence in support of the model, including experiments tending to show that: (1) disruption of LI is characteristic of acute, positively-symptomatic schizophrenia; (2) LI depends upon dopaminergic activity; (3) LI depends specifically upon dopamine release in n. accumbens; (4) LI depends upon the integrity of the hippocampal formation and the retrohippocampal region reciprocally connected to the hippocampal formation; (5) the roles of n. accumbens and the hippocampal system in LI are interconnected.

AB - Latent inhibition (LI) consists in a retardation of conditioning seen when to-be-conditioned stimulus is first presented a number of times without other consequence. Disruption of LI has been proposed as a possible model of the cognitive abnormality that underlies the positive psychotic symptoms of acute schizophrenia. We review here evidence in support of the model, including experiments tending to show that: (1) disruption of LI is characteristic of acute, positively-symptomatic schizophrenia; (2) LI depends upon dopaminergic activity; (3) LI depends specifically upon dopamine release in n. accumbens; (4) LI depends upon the integrity of the hippocampal formation and the retrohippocampal region reciprocally connected to the hippocampal formation; (5) the roles of n. accumbens and the hippocampal system in LI are interconnected.

KW - Hippocampal formation

KW - Latent inhibition

KW - Mesolimbic dopamine system

KW - Nucleus accumbens

KW - Schizophrenia

UR - http://www.scopus.com/inward/record.url?scp=0028802824&partnerID=8YFLogxK

U2 - 10.1016/0166-4328(95)00154-9

DO - 10.1016/0166-4328(95)00154-9

M3 - Journal article

C2 - 8747172

VL - 71

JO - Behavioural Brain Research

JF - Behavioural Brain Research

SN - 0166-4328

IS - 1-2

ER -

The role of mesolimbic dopaminergic and retrohippocampal afferents to the nucleus accumbens in latent inhibition: implications for schizophrenia

Abstract

Keywords

ASJC Scopus subject areas

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