The role of mesolimbic dopaminergic and retrohippocampal afferents to the nucleus accumbens in latent inhibition: implications for schizophrenia

Jeffrey A. Gray, Michael H. Joseph, David R. Hemsley, Andrew M.J. Young, E. Clea Warburton, Pascale Boulenguez, Gregory A. Grigoryan, Scott L. Peters, J. N.P. Rawlins, C. T. Taib, Kay Yan Benjamin Yee, Helen Cassaday, Ina Weiner, Gilad Gal, Oleg Gusak, Daphna Joel, Eran Shadach, Uri Shalev, Ricardo Tarrasch, Joram Feldon

Research output: Journal article publicationJournal articleAcademic researchpeer-review

150 Citations (Scopus)

Abstract

Latent inhibition (LI) consists in a retardation of conditioning seen when to-be-conditioned stimulus is first presented a number of times without other consequence. Disruption of LI has been proposed as a possible model of the cognitive abnormality that underlies the positive psychotic symptoms of acute schizophrenia. We review here evidence in support of the model, including experiments tending to show that: (1) disruption of LI is characteristic of acute, positively-symptomatic schizophrenia; (2) LI depends upon dopaminergic activity; (3) LI depends specifically upon dopamine release in n. accumbens; (4) LI depends upon the integrity of the hippocampal formation and the retrohippocampal region reciprocally connected to the hippocampal formation; (5) the roles of n. accumbens and the hippocampal system in LI are interconnected.
Original languageEnglish
JournalBehavioural Brain Research
Volume71
Issue number1-2
DOIs
Publication statusPublished - 1 Jan 1995
Externally publishedYes

Keywords

  • Hippocampal formation
  • Latent inhibition
  • Mesolimbic dopamine system
  • Nucleus accumbens
  • Schizophrenia

ASJC Scopus subject areas

  • Behavioral Neuroscience

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