The relationships between brain structural changes and perceived loneliness in older adults suffering from late-life depression

Emily L.L. Sin, Ho Ling Liu, Shwu Hua Lee, Chih Mao Huang, Yau Yau Wai, Yao Liang Chen, Che Hin Chan, Chemin Lin, Tatia M.C. Lee

Research output: Journal article publicationJournal articleAcademic researchpeer-review

10 Citations (Scopus)


Objective: Late-life depression is a significant health risk factor for older adults, part of which is perceived loneliness. In this voxel-based morphometry study, we examined the relationships between perceived loneliness and depression recurrence. Methods: Fifty-two older adults were recruited, and they were split into 3 groups: single episode, multiple episodes, or normal control groups, according to their clinical histories. Results: This result suggests the level of functioning regarding the reward system may be negatively related to the number of depressive episodes. Taken together, the findings of this study offer important insight into the neural underpinnings of the course and chronicity of late-life depression.

Original languageEnglish
Pages (from-to)606-612
Number of pages7
JournalInternational Journal of Geriatric Psychiatry
Issue number4
Publication statusPublished - 1 Apr 2018


  • late-life depression
  • MRI
  • perceived loneliness
  • voxel-based morphometry

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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