The rational design of a peptide-based hydrogel responsive to H2S

Raoul Peltier, Ganchao Chen, Haipeng Lei, Mei Zhang, Liqian Gao, Su Seong Lee, Zuankai Wang, Hongyan Sun

Research output: Journal article publicationJournal articleAcademic researchpeer-review

39 Citations (Scopus)


The development of hydrogels that are responsive to external stimuli in a well-controlled manner is important for numerous biomedical applications. Herein we reported the first example of a hydrogel responsive to hydrogen sulphide (H2S). H2S is an important gasotransmitter whose deregulation has been associated with a number of pathological conditions. Our hydrogel design is based on the functionalization of an ultrashort hydrogelating peptide sequence with an azidobenzyl moiety, which was reported to react with H2S selectively under physiological conditions. The resulting peptide was able to produce hydrogels at a concentration as low as 0.1 wt%. It could then be fully degraded in the presence of excess H2S. We envision that the novel hydrogel developed in this study may provide useful tools for biomedical research.

Original languageEnglish
Pages (from-to)17273-17276
Number of pages4
JournalChemical Communications
Issue number97
Publication statusPublished - 2 Oct 2015
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • General Chemistry
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry


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